What conditions can cause circumferential ileal thickening on CT besides Crohn disease?

Differential Diagnosis of Circumferential Ileal Thickening on CT

Circumferential ileal thickening on CT has a broad differential diagnosis beyond Crohn's disease, including infectious enteritis, ischemia, NSAID enteropathy, radiation enteritis, vasculitis, angioedema, graft-versus-host disease, mucositis, backwash ileitis, and lymphoma. 1

Key Imaging Features That Guide Diagnosis

Pattern of Enhancement and Symmetry

• Symmetric, homogeneous transmural enhancement suggests benign processes including edema, ischemia, infectious enteritis, or shock bowel rather than Crohn's disease 1
• Asymmetric thickening (particularly affecting the mesenteric border more than antimesenteric) is a specific finding for Crohn's disease 1
• Stratified (bi- or tri-laminar) enhancement can occur in both Crohn's disease and other causes of segmental hyperenhancement 1

Degree of Wall Thickening

• Mild thickening (3-5 mm), moderate (5-9 mm), or severe (≥10 mm) can occur with multiple etiologies 1, 2
• Wall thickening >1.5 cm with mass-like features or extension into adjacent mesentery raises concern for malignancy, particularly lymphoma 1

Specific Conditions to Consider

Infectious Enteritis

• Produces segmental mural hyperenhancement and wall thickening similar to Crohn's disease 1
• Typically presents with symmetric, circumferential thickening 3
• Clinical context (acute onset, fever, diarrhea) and stool studies help differentiate 2

Ischemic Bowel Disease

• Demonstrates circumferential, symmetric wall thickening with fold enlargement 3
• Homogeneous enhancement pattern is common 1
• Look for mesenteric vascular occlusion or low-flow states 2

NSAID Enteropathy

• Causes segmental mural hyperenhancement and thickening indistinguishable from Crohn's on imaging 1
• Medication history is critical for diagnosis 2

Radiation Enteritis

• Clinical history of prior radiation therapy is the key diagnostic clue 1, 3
• CT findings are nonspecific and can mimic inflammatory bowel disease 3

Vasculitis and Angioedema

• Both produce segmental mural hyperenhancement 1
• Angioedema typically shows symmetric thickening without mesenteric inflammatory changes 1

Graft-versus-Host Disease

• Causes small bowel and colonic wall thickening 1, 3
• History of bone marrow transplantation is diagnostic 3

Lymphoma

• Can present with symmetric, homogeneous wall thickening mimicking benign disease 4, 5
• Focal thickening >1.5 cm with mass effect or extensive adenopathy suggests malignancy 1

Critical Diagnostic Algorithm

Step 1: Assess Enhancement Pattern

• If asymmetric with mesenteric findings (comb sign, creeping fat, enlarged vasa recta): strongly favor Crohn's disease 1
• If symmetric and homogeneous: consider ischemia, infectious enteritis, or other benign processes 1

Step 2: Evaluate Clinical Context

• Acute presentation with fever: infectious enteritis 2, 3
• Medication history: NSAID enteropathy 1
• Prior radiation: radiation enteritis 1, 3
• Immunosuppression/transplant: graft-versus-host disease 3

Step 3: Look for Associated Findings

• Mesenteric stranding disproportionate to wall thickening: inflammatory conditions 4
• Vascular occlusion or low-flow state: ischemia 2, 3
• Extensive lymphadenopathy or mass effect: lymphoma 1

Step 4: Consider Advanced Imaging

• MR enterography is preferred over CT when Crohn's disease remains in the differential, as it provides superior assessment of intramural edema (T2 hyperintensity) and restricted diffusion without radiation exposure 1, 2
• Unenhanced MRE with diffusion-weighted imaging is acceptable if IV contrast cannot be administered 1

Step 5: Proceed to Tissue Diagnosis When Needed

• Endoscopy (ileocolonoscopy or enteroscopy) is indicated when imaging shows bowel wall thickening without a clear diagnosis 2
• Biopsy provides definitive diagnosis and distinguishes inflammatory from neoplastic processes 2

Common Pitfalls to Avoid

• Do not assume all circumferential ileal thickening is Crohn's disease—the differential is extensive and requires systematic evaluation 1
• Underdistended or contracted bowel loops can create false appearance of thickening; only measure thickness in well-distended segments 1
• Mural hyperenhancement without wall thickening is nonspecific and may reflect inflammation or other processes 1
• Stratified enhancement alone does not confirm Crohn's disease, as it occurs with multiple other causes 1