From the FDA Drug Label
Nimodipine has been shown, in 4 randomized, double-blind, placebo-controlled trials, to reduce the severity of neurological deficits resulting from vasospasm in patients who have had a recent subarachnoid hemorrhage (SAH). The medical treatment for Reversible Cerebral Vasoconstriction Syndrome (RCVS) is not explicitly stated in the provided drug label. However, based on the information provided, nimodipine may be considered as a potential treatment option for cerebral vasospasm, which is a related condition.
- The key points to consider are: + Nimodipine is a calcium channel blocker that inhibits contractions of vascular smooth muscle. + It has been shown to reduce the severity of neurological deficits resulting from vasospasm in patients with subarachnoid hemorrhage (SAH) 1. However, it is essential to note that the provided drug label does not directly address the treatment of Reversible Cerebral Vasoconstriction Syndrome (RCVS).
From the Research
Medical Treatment for Reversible Cerebral Vasoconstriction Syndrome (RCVS)
The medical treatment for RCVS typically involves the use of calcium channel blockers and supportive care.
- Calcium channel blockers such as verapamil and nimodipine have been used to treat RCVS, with reported reduction of headache intensity 2, 3, 4, 5.
- Glucocorticoids have been reported as an independent predictor of worse outcome and should be avoided 3.
- Intra-arterial vasodilators infusion has been used in some cases, particularly in severe or deteriorating cases 6.
- Supportive care, including bed rest and analgesics, is also an important part of RCVS management 3.
- The removal of precipitating factors, such as vasoactive medications or illicit drugs, is also crucial in the management of RCVS 3.
Treatment Options
The following treatment options have been reported in the literature:
- Oral verapamil, with a common dosing regimen of controlled release 120 mg once daily 4.
- Intra-arterial verapamil, which has been used in some cases 6, 4.
- Nimodipine, which has been used as an alternative to verapamil 3, 5.
- Long-acting verapamil, which has been reported to have a greater effect on velocities compared to nimodipine and shorter-acting calcium channel blockers 5.
Monitoring and Diagnosis
Transcranial Doppler ultrasound (TCD) has been used to monitor therapeutic response and detect changes in the acute setting 5.