From the Guidelines
Hypotension Risk with Robaxin (Methocarbamol)
Robaxin (Methocarbamol) can cause hypotension, as evidenced by its cardiovascular effects which include bradycardia and hypotension 1.
- The precise mechanism of action of Methocarbamol is unclear, but its adverse effects profile indicates a potential risk for hypotension.
- Drowsiness and dizziness are also among the adverse effects, suggesting that Methocarbamol may have a broader impact on the cardiovascular system and overall patient stability 1.
- While the exact dosage and treatment duration that increase the risk of hypotension are not specified in the provided evidence, it is crucial for clinicians to be aware of this potential side effect, especially in patients with pre-existing cardiovascular conditions.
- The elimination of Methocarbamol is significantly impaired in certain conditions, which could potentially lead to increased levels of the drug in the body and a higher risk of adverse effects, including hypotension 1.
From the FDA Drug Label
ADVERSE REACTIONS ... Cardiovascular system: Bradycardia, flushing, hypotension, syncope, thrombophlebitis OVERDOSAGE ... Overdose of methocarbamol ... includes the following symptoms: ... hypotension, seizures, and coma.
Yes, Robaxin (Methocarbamol) can cause hypotension, as it is listed as a potential adverse reaction in the drug label 2 and also as a symptom of overdose 2.
From the Research
Orthostatic Hypotension and Medications
The relationship between medications and orthostatic hypotension is well-documented in various studies 3, 4. Orthostatic hypotension is defined as a drop in systolic blood pressure of at least 20mmHg or a drop in diastolic blood pressure of at least 10mmHg within 3 minutes of standing 5.
Medications that Can Cause Hypotension
Several medications can cause hypotensive effects, including:
- Diuretics and vasodilators, which are commonly used to treat hypertension 3
- Tricyclic antidepressants, such as imipramine, which can cause orthostatic hypotension 4
- Monoamine-oxidase inhibitors, which can cause orthostatic hypotension or hypertensive crisis due to tyramine-containing food 4
- Serotonin-norepinephrine reuptake inhibitors, such as venlafaxine, which can increase the risk of hypertension 4
- Dopamine-norepinephrine reuptake inhibitors, such as bupropion, which can lead to blood pressure increases or orthostatic hypotension 4
Robaxin (Methocarbamol) and Hypotension
There is no direct evidence in the provided studies that links Robaxin (Methocarbamol) to hypotension. However, it is essential to note that Robaxin is a muscle relaxant that can cause drowsiness, dizziness, and lightheadedness, which may increase the risk of falls, especially in older adults 6, 3.
Key Points
- Orthostatic hypotension is a common disorder that can be caused by various medications and medical conditions 5, 3
- Medications that can cause hypotensive effects should be used with caution, especially in older adults and patients with cardiovascular diseases 3, 4
- Patients taking medications that can cause hypotension should be monitored regularly for signs and symptoms of orthostatic hypotension 6, 5