Can diazepam (Valium) be used as a short‑term rescue medication for acute severe vertigo in adults, and what is the recommended dosing schedule?

Diazepam (Valium) for Acute Vertigo

Diazepam can be used as a short-term rescue medication for acute severe vertigo in adults, but only for 3–5 days maximum during disabling vestibular attacks—not for benign paroxysmal positional vertigo (BPPV), which requires repositioning maneuvers instead. 1

When to Use Diazepam

Appropriate indications:

• Severe acute vestibular attacks (vestibular neuritis, Ménière's disease) that prevent normal functioning and cause disabling symptoms 1, 2
• Short-term symptom control during the first 3–5 days of acute vertigo when symptoms are so severe the patient cannot tolerate repositioning maneuvers or vestibular rehabilitation 3, 1
• Psychological anxiety secondary to severe vertigo episodes, where benzodiazepines may reduce functional and emotional distress scores 3

Explicit contraindications:

• BPPV should never be treated with diazepam—canalith repositioning maneuvers (Epley, Semont) achieve 80–93% improvement versus only 30% with medication alone 3, 4
• During vestibular rehabilitation therapy, as benzodiazepines impede the central compensation process essential for long-term recovery 1
• Chronic or maintenance therapy for any vertigo condition 1, 2

Recommended Dosing

Acute dosing regimen:

• Oral: 0.25–0.50 mg/kg (maximum 20 mg per dose) for adults 3
• Standard adult dose: 5–10 mg orally once or twice daily 5
• Intramuscular: 10 mg once or twice daily for severe cases unable to tolerate oral medication 5
• Duration: Maximum 3–5 days, then discontinue to allow vestibular compensation 1, 2

The 2022 meta-analysis of 17 randomized trials involving 1,586 patients found that single-dose antihistamines provided significantly greater vertigo relief at 2 hours than single-dose benzodiazepines (16.1-point greater improvement on 100-point VAS), and benzodiazepines showed no superiority over placebo at 1 week or 1 month 6. A 2017 emergency department trial confirmed that diazepam 5 mg and meclizine 25 mg were equally effective, with mean VAS improvements of 36 and 40 points respectively at 60 minutes 7.

Critical Safety Warnings

Fall risk and adverse effects:

• Benzodiazepines are an independent risk factor for falls, especially in elderly patients who already have elevated fall risk from vertigo 3, 1
• Common side effects include drowsiness, cognitive deficits, and impaired ability to drive or operate machinery 3, 1
• Polypharmacy concerns in elderly patients taking cardiovascular medications increase risk of drug-drug interactions 2

When to avoid diazepam entirely:

• Elderly patients with multiple fall risk factors 1
• Patients requiring vestibular rehabilitation (wait until after acute phase) 1
• Any patient with BPPV—use repositioning maneuvers instead 3, 4

Preferred Alternatives

For BPPV (most common cause):

• Epley or Semont maneuvers as first-line treatment—80% success with 1–3 treatments 4
• Antiemetics (prochlorperazine 5–10 mg) only for severe nausea during maneuvers 3, 2

For non-BPPV peripheral vertigo:

• Meclizine 25–100 mg daily as-needed is preferred over benzodiazepines for most patients 2, 4
• Prochlorperazine 5–10 mg for severe nausea/vomiting (maximum 3 doses per 24 hours) 2

For long-term management:

• Vestibular rehabilitation therapy is more effective than prolonged medication use and should begin within the first week after acute symptoms subside 1, 2

Clinical Decision Algorithm

1. Confirm diagnosis: Distinguish BPPV (positional triggers, brief episodes) from other peripheral vertigo (spontaneous, prolonged) 4
2. If BPPV: Perform Dix-Hallpike test and treat with repositioning maneuvers—do not prescribe diazepam 3, 4
3. If severe acute vestibular attack (vestibular neuritis, Ménière's): Consider diazepam 5–10 mg for 3–5 days maximum 1, 5
4. Reassess within 1 month to document resolution or persistence, and transition to vestibular rehabilitation 3, 2
5. Discontinue benzodiazepines before starting vestibular rehabilitation to avoid impeding compensation 1

Common Pitfalls to Avoid

• Do not prescribe diazepam for >10–15 days per month—this can cause medication-overuse rebound vertigo 2
• Do not combine diazepam with repositioning maneuvers—patients who received Epley maneuver alone recovered faster than those who also received vestibular sedatives 3
• Do not use diazepam as prophylaxis except in patients with documented severe nausea during prior repositioning procedures 3, 1