Is this complete blood count (CBC) with WBC 10.1 ×10³/µL, neutrophils 7.2 ×10³/µL, lymphocytes 2.2 ×10³/µL, monocytes 0.56 ×10³/µL, eosinophils 0.051 ×10³/µL, basophils 0.04 ×10³/µL, RBC 4.69 ×10⁶/µL, hemoglobin 13.9 g/dL, hematocrit 43.5 %, MCV 92.8 fL, MCH 29.6 pg, MCHC 32.0 g/dL, RDW 13.9 %, platelets 320 ×10³/µL, MPV 11.3 fL normal or concerning?

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Complete Blood Count Interpretation

This CBC is entirely normal and requires no immediate action or further workup.

All values fall comfortably within the reference ranges provided, and there are no concerning patterns or abnormalities that would suggest underlying pathology.

Detailed Component Analysis

White Blood Cell Parameters

  • Total WBC 10.1 × 10³/µL is within the normal range (3.8–10.8) and represents a mid-normal value with no concern for leukopenia or leukocytosis 1, 2.
  • Absolute neutrophil count (ANC) 7,232 cells/µL is well above the critical threshold of 1,500 cells/µL that defines neutropenia, and far above the 500 cells/µL level that would trigger prophylactic antimicrobial therapy 2.
  • Lymphocytes 2,222 cells/µL fall within the normal range (850–3,900), with no evidence of lymphopenia or lymphocytosis 1.
  • Monocytes 556 cells/µL, eosinophils 51 cells/µL, and basophils 40 cells/µL are all within their respective normal ranges 1.

Red Blood Cell Parameters

  • RBC 4.69 × 10⁶/µL, hemoglobin 13.9 g/dL, and hematocrit 43.5% are all normal, excluding anemia (which would require hemoglobin <11.7 g/dL in this reference range) 1.
  • MCV 92.8 fL is normocytic (normal range 81.4–101.7), ruling out microcytic or macrocytic processes 1.
  • MCH 29.6 pg and MCHC 32.0 g/dL are within normal limits 1.
  • RDW 13.9% is at the upper end of normal (11.0–15.0%) but not elevated; an elevated RDW would suggest mixed red cell populations or iron deficiency 1, 3.

Platelet Parameters

  • Platelets 320 × 10³/µL are well within the normal range (140–400), with no thrombocytopenia or thrombocytosis 1.
  • MPV 11.3 fL is normal (7.5–12.5), indicating appropriate platelet size 1.

Clinical Context

No high-risk features are present:

  • The neutrophil count is robust, providing no concern for infection risk that would require prophylaxis (which is only indicated when ANC <500 cells/µL for >7 days) 2.
  • There is no anemia, thrombocytopenia, or leukopenia that would warrant investigation for bone marrow pathology, nutritional deficiencies, or hemolysis 1, 3.
  • The normal RDW argues against early iron deficiency, mixed nutritional deficiencies, or myelodysplastic syndrome 1, 3.

Recommendation

No further testing, monitoring, or intervention is needed based on this CBC alone. If clinical symptoms develop (fever, fatigue, bleeding, recurrent infections), repeat evaluation would be appropriate at that time 1, 4.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Neutropenia Management and Classification

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Guideline for Evaluating a Normal CBC with Marked Red‑Cell Morphologic Abnormalities

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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