Is nitrofurantoin (Macrobid) an appropriate oral treatment for a urinary tract infection caused by an ESBL‑producing Escherichia coli?

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Last updated: February 27, 2026 • View editorial policy

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Related Questions

Is Nitrofurantoin (antibiotic) effective for treating a complicated Urinary Tract Infection (UTI) caused by Extended-Spectrum Beta-Lactamase (ESBL) producing bacteria?

Can nitrofurantoin be used to treat uncomplicated urinary tract infections (UTIs) caused by Extended-Spectrum Beta-Lactamase (ESBL) producing Escherichia coli (E. coli)?

What is the recommended treatment for a 91-year-old female with a urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL) producing Escherichia coli (E. coli), susceptible to meropenem and gentamicin, with a history of chronic pneumonitis potentially related to previous Macrobid (nitrofurantoin) use and a sulfa allergy?

What is the best treatment option for an elderly patient with a urinary tract infection (UTI) caused by Klebsiella pneumoniae and Escherichia coli (E. coli), who is not responding to Macrobid (Nitrofurantoin) and is experiencing dysuria and hyperthermia?

What is the best oral (PO) antibiotic for a patient with normal kidney function and no known allergies, diagnosed with Extended-Spectrum Beta-Lactamase (ESBL)-producing bacteria in their urine?

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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