What is the diagnosis for a patient with acute cholecystitis (inflammation of the gallbladder) shown on ultrasound (US) with signs of pancreatitis, but normal lipase levels?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 26, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

En un paciente con colecistitis calculosa que muestra signos de pancreatitis en la ecografía a pesar de una lipasa normal, recomiendo una consulta quirúrgica urgente para colecistectomía después de un manejo médico inicial con fluidos intravenosos, control del dolor (acetaminofén o AINE, con opioides si es necesario) y antibióticos de amplio espectro (como piperacilina-tazobactam 3,375 g IV cada 6 horas o ceftriaxona 1-2 g IV diario más metronidazol 500 mg IV cada 8 horas). El paciente debe permanecer en ayunas inicialmente, con una avanzada gradual de la dieta según sea tolerada. Esta presentación sugiere una inflamación inducida por cálculos que afecta tanto a la vesícula biliar como al páncreas, incluso sin elevación de la lipasa. La lipasa normal no excluye la pancreatitis, ya que los niveles de enzimas pueden normalizarse rápidamente o permanecer normales en casos leves. Los hallazgos de la ecografía son significativos y deben guiar el manejo. Retrasar el tratamiento podría llevar a complicaciones como la perforación, la formación de abscesos o la progresión de la pancreatitis, por lo que la intervención oportuna es esencial incluso con valores de laboratorio discordantes 1.

Algunos puntos clave a considerar en el manejo de esta condición incluyen:

  • La colecistitis calculosa es una condición que requiere un manejo quirúrgico oportuno para prevenir complicaciones 1.
  • La pancreatitis puede ocurrir en pacientes con colecistitis calculosa, incluso sin elevación de la lipasa 1.
  • La ecografía es una herramienta valiosa para diagnosticar la colecistitis calculosa y la pancreatitis 1.
  • El manejo médico inicial con fluidos intravenosos, control del dolor y antibióticos de amplio espectro es crucial para estabilizar al paciente antes de la intervención quirúrgica.
  • La colecistectomía es el tratamiento de elección para la colecistitis calculosa, y debe realizarse lo antes posible para prevenir complicaciones 1.

From the Research

Calculating Cholecystitis with US Showing Signs of Pancreatitis, Lipase Normal

  • The presentation of acute cholecystitis can be atypical, with variable imaging appearances and overlapping clinical manifestations with other conditions such as biliary colic, acute hepatitis, pancreatitis, and cholangiopathies 2.
  • Ultrasound (US) is still used as the initial imaging technique for evaluating patients with suspected acute calculous cholecystitis due to its high sensitivity in detecting gallbladder stones, real-time character, speed, and portability 3.
  • Helpful sonographic findings of acute cholecystitis include a dilated gallbladder, increased intraluminal pressures, intraluminal sludge, wall hyperemia, mucosal ischemic changes, pericholecystic inflammation, and mucosal discontinuity 2.
  • The sonographic Murphy sign, while helpful if positive, is relatively insensitive for accurate diagnosis of acute cholecystitis, and overreliance on it results in low diagnostic accuracy in practice 2.
  • In cases where US shows signs of pancreatitis but lipase levels are normal, it is essential to consider other diagnostic criteria and imaging modalities, such as CT or MRI, to evaluate the full extent of potential complications 4.
  • Acute cholecystitis may not always present with classic diagnostic criteria, including laboratory results and physical exam findings, but a thorough work-up can be effective in diagnosis 5.

Related Questions

What is the plan for a patient with calculous cholecystitis (inflammation of the gallbladder due to gallstones) shown on Ultrasound (US) with signs of pancreatitis, but normal lipase levels?
What is the most appropriate initial investigation for a 38-year-old woman with epigastric pain, vomiting, and multiple small gallstones, presenting with abdominal distention, epigastric tenderness, and abnormal laboratory results, including elevated alkaline phosphatase, amylase, direct bilirubin, and total bilirubin levels?
What is the diagnosis and treatment for acalculous (without gallstones) cholecystitis?
What are the clinical manifestations of acute cholecystitis presenting with Murphy's sign?
What is the initial management for a 26-year-old female with right upper quadrant (RUQ) pain and fever 2 weeks post-laparoscopic cholecystectomy (removal of the gallbladder using a minimally invasive technique) for acute cholecystitis (inflammation of the gallbladder) due to gallstones?
What is the management of a dusky, non-functioning ileostomy (intestinal stoma) 24 hours after an operation for intestinal obstruction?
What is the cause of chronic diarrhea and persistent hypokalemia in a 63-year-old patient with a history of diabetes mellitus (DM) and a previous road traffic accident (RTA) with an intracranial hematoma, presenting with stool analysis showing mucous (+)?
What is the next step in managing a dusky loop in an umbilical hernia (Umbilical Hernia) with signs of venous congestion, potentially leading to gangrene characterized by coagulative necrosis, and serous fluid leakage, considering repair with mesh?
What is the diagnosis for a patient with calculous cholecystitis (inflammation of the gallbladder due to gallstones) shown on Ultrasound (US) with signs of pancreatitis, but normal lipase levels?
What is the plan for a patient with calculous cholecystitis (inflammation of the gallbladder due to gallstones) shown on Ultrasound (US) with signs of pancreatitis, but normal lipase levels?
Does a patient with calculous cholecystitis and ultrasound (US) signs of pancreatitis, but normal lipase levels, require a computed tomography (CT) scan?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.