Differential Diagnosis for Thrombocytopenia + GNR Sepsis + New Cardiomyopathy
- Single Most Likely Diagnosis
- Sepsis-induced cardiomyopathy with thrombocytopenia: This is the most likely diagnosis given the combination of GNR sepsis, new cardiomyopathy, and thrombocytopenia. Sepsis can cause both cardiomyopathy and thrombocytopenia due to the systemic inflammatory response and consumption of platelets.
- Other Likely Diagnoses
- Endocarditis: GNR sepsis could be a result of endocarditis, which can also cause new cardiomyopathy and thrombocytopenia due to embolic events and immune complex deposition.
- Disseminated intravascular coagulation (DIC): Sepsis can trigger DIC, leading to thrombocytopenia and cardiomyopathy due to microthrombi formation and consumption of coagulation factors.
- Do Not Miss Diagnoses
- Neutropenic sepsis with cardiac involvement: Although less common, neutropenia can increase the risk of GNR sepsis, and the cardiac involvement could be due to the sepsis itself or an underlying condition such as leukemia.
- Toxic shock syndrome: This condition, caused by bacterial toxins, can present with sepsis, cardiomyopathy, and thrombocytopenia, and is critical to identify due to its high mortality rate if not promptly treated.
- Rare Diagnoses
- Lymphoma or leukemia with cardiac involvement: Certain types of lymphoma or leukemia can cause cardiomyopathy and thrombocytopenia, and may also increase the risk of GNR sepsis due to immunosuppression.
- Cardiac amyloidosis: Although rare, cardiac amyloidosis can cause new cardiomyopathy, and some forms of amyloidosis can increase the risk of thrombocytopenia and infections due to splenic involvement or immunoglobulin abnormalities.