From the Guidelines
Magnesium lysonate is not a recommended treatment for chronic idiopathic constipation, as the most recent and highest quality study suggests that magnesium oxide (MgO) is a more effective and well-studied option for this condition. According to the american gastroenterological association-american college of gastroenterology clinical practice guideline 1, MgO has been shown to increase the number of complete spontaneous bowel movements (CSBMs) per week and stool-based bowel movements (SBMs) per week, with a higher treatment response compared to placebo. The guideline also notes that MgO may have better quality-of-life scores and stool consistency compared to placebo 1.
When considering the use of magnesium supplements, it is essential to note that the bioavailability and clinical efficacy of formulations other than MgO, such as magnesium lysonate, are unknown 1. Additionally, individuals with significant renal impairment should avoid magnesium supplements due to the risk of hypermagnesemia 1.
In terms of dosage, the guideline suggests starting at a lower dose, which may be increased if necessary, and avoiding use in patients with renal insufficiency due to the risk of hypermagnesemia 1. Typical dosages of MgO range from 500 mg/d to 1.5 g/d, although lower doses may be used in clinical practice 1.
Key points to consider when using magnesium supplements include:
- MgO is a more effective and well-studied option for chronic idiopathic constipation
- Magnesium lysonate has unknown bioavailability and clinical efficacy
- Individuals with significant renal impairment should avoid magnesium supplements
- Dosage should be started low and increased as necessary
- MgO may have better quality-of-life scores and stool consistency compared to placebo
From the Research
Magnesium Lysonate Uses
- Magnesium lysonate is not directly mentioned in the provided studies, however, the uses of magnesium in general can be inferred from the texts.
- Magnesium is used to treat hypomagnesemia, a condition characterized by low serum magnesium concentration 2.
- It is also used to manage conditions related to magnesium imbalance, such as secondary hypocalcemia 2.
- Magnesium replacement therapy can be administered intravenously or orally 2.
- In the context of chronic kidney disease (CKD), magnesium may play a role in inhibiting vascular calcification and reducing mortality 3.
- Oral magnesium oxide has been shown to be effective in retarding the progression of coronary artery calcification in non-dialysis CKD patients 3.
- Magnesium deficiency has been linked to the progression of CKD, and supplementing with magnesium may provide better cardiovascular prognosis 3.
- The treatment of magnesium deficit and excess syndromes has been reviewed, and specific treatment protocols have been formulated 4.