From the Guidelines
Zyrtec should be given to children in the evening to minimize potential sedative effects during the day. According to a study published in the Journal of Allergy and Clinical Immunology 1, cetirizine, the active ingredient in Zyrtec, has been associated with sedative properties, including mild drowsiness, in some patients. While the effect tends to be milder than that observed with first-generation antihistamines, patients given this drug for allergic rhinitis should be cautioned regarding this risk. The study found that cetirizine 10 mg may be associated with mild drowsiness (13.7% for patients age 12 years) compared with placebo (6.3%) 1.
Key Considerations
- The standard dosing for children depends on age, and the medication is effective for 24 hours with a single dose, so timing is less critical for symptom control 1.
- If a child experiences significant daytime allergies, morning administration might be more beneficial, but this should be discussed with the child's healthcare provider.
- It is essential to follow the dosing instructions provided by the child's healthcare provider and use the measuring device that comes with the medication for accurate dosing.
Sedative Effects
- The study found that cetirizine has sedative properties, which can be a concern for children, especially during the day 1.
- Other antihistamines, such as fexofenadine, loratadine, and desloratadine, have not been associated with sedative properties at recommended doses, but may have sedative effects at higher doses or in certain individuals 1.
Administration Timing
- Evening administration of Zyrtec can help minimize potential sedative effects during the day, allowing children to be more alert and focused in school or during daily activities.
- However, the timing of administration should be individualized based on the child's specific needs and response to the medication, and should be discussed with the child's healthcare provider.
From the FDA Drug Label
Directions Adults and children 6years and overone 10 mg tablet once daily, do not take more than one 10 mg tablet in 24 hours. The FDA drug label does not answer the question.
From the Research
Administration Timing for Zyrtec in Children
- The provided studies do not specifically address the optimal timing of Zyrtec administration in children.
- However, the studies discuss the efficacy and duration of action of various antihistamines, including fexofenadine (the active ingredient in Zyrtec) and cetirizine, in adults and adolescents with seasonal allergic rhinitis 2, 3, 4, 5, 6.
- Fexofenadine is shown to have a rapid onset of action, with relief from symptoms within 2 hours, and a long duration of action, making it suitable for once-daily administration 2.
- The studies suggest that cetirizine may have a longer duration of effect than fexofenadine, with greater relief of symptoms at 12 hours postdose and over the 5- to 12-hour postdose period 5, 6.
- While the optimal timing of Zyrtec administration in children is not directly addressed, the once-daily administration of fexofenadine may be suitable for children, given its long duration of action and rapid onset of relief.
- It is essential to consult with a healthcare professional to determine the best administration schedule for Zyrtec in children, taking into account individual needs and circumstances.