What causes neuropraxia?

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Last updated: February 17, 2025View editorial policy

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From the Guidelines

Neuropraxia is primarily caused by stretch or blunt injury to the nerve, which may not always be visibly detectable [ 1 ].

Common Causes of Neuropraxia

  • Surgical procedures: Neuropraxia can occur during surgeries, such as thyroidectomy, due to stretch at the ligament of Berry [ 1 ]
  • Trauma: Traumatic injuries, including fractures or dislocations, can also cause neuropraxia
  • Nerve compression: Prolonged compression of a nerve, such as during surgical procedures or from improper positioning, can lead to neuropraxia [ 1 ]

Characteristics of Neuropraxia

  • Temporary disruption of nerve conduction: Neuropraxia is characterized by a temporary disruption of nerve conduction, which can resolve on its own without specific treatment [ 1 ]
  • Recovery time: Symptoms of neuropraxia typically resolve within a few weeks to months, usually 6-12 weeks, without specific treatment, aside from removal of the offending agent or correction of the underlying cause [ 1 ]

From the Research

Causes of Neuropraxia

  • Neuropraxia is a type of nerve injury that can occur due to various causes, including motor vehicle accidents, falls, industrial accidents, household accidents, and penetrating trauma 2
  • Compression neuropathies, also known as entrapment neuropathies, can cause neuropraxia, often due to mechanical injury, either compression or stretch of the affected nerve 3
  • Ischemic and mechanical factors are involved in the development of compression neuropathy, which can lead to neuropraxia 4
  • Neuropraxia can also occur as a complication of surgery, such as liver transplantation, particularly with longer duration of surgery 5
  • Other causes of neuropraxia include compression due to pseudoaneurysm, such as a false brachial artery aneurysm 6

Mechanisms of Neuropraxia

  • The development of compression neuropathy, which can lead to neuropraxia, involves a dose-response curve, where the greater the duration and amount of pressure, the more significant the neural dysfunction 4
  • Fibrosis and thickening of the external epineurium and perineurium can interfere with blood flow and produce dynamic ischemia to the nerve fibers, leading to neuropraxia 4
  • Decreased neural gliding and movement of the nerve in the extremity can also contribute to the development of neuropraxia 4

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Common Compression Neuropathies.

Clinics in geriatric medicine, 2021

Research

Pathophysiology of nerve compression.

Hand clinics, 2002

Research

Neuropraxia: An Underappreciated Morbidity of Liver Transplantation.

The Journal of surgical research, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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