What is the likely diagnosis of a tender breast mass in a prepubertal girl?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 27, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for an 8-year-old Girl with a Breast Mass

  • Single most likely diagnosis
    • Breast bud (thelarche): This is the most common cause of breast masses in prepubertal girls, typically presenting as a firm, tender mass behind the nipple. The patient's age and the description of the mass are consistent with this diagnosis.
  • Other Likely diagnoses
    • Cyst: Breast cysts can occur in young girls and may present as tender, firm masses.
    • Fibroadenoma: Although less common in prepubertal girls, fibroadenomas can occur and present as firm, mobile masses.
    • Infection or abscess: Although there is no overlying erythema, a localized infection or abscess could still be considered, especially if the mass is tender.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Breast cancer: Although extremely rare in children, breast cancer must be considered to avoid delayed diagnosis.
    • Sarcoma (e.g., phyllodes tumor): These rare tumors can present as breast masses and require prompt diagnosis and treatment.
    • Granulomatous disease (e.g., tuberculosis): In rare cases, granulomatous diseases can manifest as breast masses.
  • Rare diagnoses
    • Hemangioma: A benign vascular tumor that can present as a breast mass, although rare in this location.
    • Neurofibroma: A rare tumor that can occur in the breast tissue, often associated with neurofibromatosis type 1.
    • Teratoma: A rare, benign tumor that can contain multiple tissue types and present as a breast mass.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.