Is Amitriptyline (Endep) associated with hair loss?

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Last updated: April 28, 2025View editorial policy

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From the Guidelines

Endep (amitriptyline) can potentially cause hair loss as a side effect, though it is relatively uncommon, and this is not explicitly mentioned in the provided study 1. However, considering the potential side effects of antidepressants, it is plausible that hair loss could be associated with Endep. The study 1 discusses various treatments for chronic migraine, including antidepressants like amitriptyline, but does not specifically address hair loss as a side effect. Given the information available, if you're experiencing hair loss while taking Endep, it's likely due to the medication's effect on hair follicles during their growth phase, causing them to prematurely enter the resting phase. This type of hair loss is typically temporary and reversible once the medication is discontinued or the body adjusts to it. Some key points to consider:

  • The hair loss is usually diffuse, meaning it occurs evenly across the scalp rather than in patches.
  • If hair loss is concerning you, don't stop taking Endep abruptly, but instead consult your healthcare provider.
  • They may adjust your dosage, switch you to an alternative medication, or recommend supportive treatments like gentle hair care practices and nutritional supplements.
  • Most cases of medication-induced hair loss improve within 3-6 months after addressing the cause.
  • While dealing with this side effect, maintaining good overall health with adequate nutrition, particularly proteins, vitamins, and minerals essential for hair growth, can be beneficial.

From the Research

Endep and Hair Loss

There is no direct evidence in the provided studies that links Endep to hair loss.

Related Studies on Hair Loss

  • The study 2 discusses the effects of nutrient deficiency and supplement use on hair loss, but does not mention Endep.
  • The studies 3 and 4 focus on the use of minoxidil for treating hair loss, particularly androgenetic alopecia, and do not mention Endep.
  • The study 5 reviews the evidence behind dietary and alternative approaches to managing thyroid disease, but does not discuss Endep or its potential effects on hair loss.

Conclusion Not Available

As per the guidelines, no conclusion can be drawn, and the response must only provide information based on the available evidence.

No Direct Evidence

There are no research papers provided that directly assist in answering the question about Endep and hair loss.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Diet and hair loss: effects of nutrient deficiency and supplement use.

Dermatology practical & conceptual, 2017

Research

Minoxidil: a comprehensive review.

The Journal of dermatological treatment, 2022

Research

Oral minoxidil treatment for hair loss: A review of efficacy and safety.

Journal of the American Academy of Dermatology, 2021

Research

Thyroid, Diet, and Alternative Approaches.

The Journal of clinical endocrinology and metabolism, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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