What are the optimal methods to achieve conception quickly?

From the Guidelines

To get pregnant fast, have regular unprotected sex during your fertile window, which occurs about 12-16 days before your next period starts, and track your menstrual cycle using apps, ovulation predictor kits, or by monitoring cervical mucus changes, as recommended by the American Society for Reproductive Medicine (ASRM) 1. When trying to conceive, it's essential to understand the fertile window and maximize fertility.

• Track your menstrual cycle using apps, ovulation predictor kits, or by monitoring cervical mucus changes (it becomes clear and slippery during ovulation) 1.
• Have sex every 1-2 days during this fertile period, as sperm can survive for up to 5 days in the female reproductive tract.
• Maintain a healthy lifestyle by eating nutritiously, exercising moderately, maintaining a healthy weight, taking prenatal vitamins with folic acid (400-800 mcg daily), and avoiding smoking, excessive alcohol, and caffeine, as these factors can affect fertility 1.
• Men should avoid hot tubs and tight underwear as these can affect sperm quality.
• If you're over 35 or have been trying unsuccessfully for 6-12 months, consult a healthcare provider for fertility testing and possible interventions, as female fertility decreases gradually but significantly after age 32 years, and faster after 37 years 1.
• Reducing stress through relaxation techniques may also help, as high stress levels can disrupt hormonal balance and ovulation patterns. It's crucial to note that fertility rates are lower among women who are very thin or obese, and those who consume high levels of caffeine (e.g., more than five cups per day), and that smoking, consuming alcohol, using recreational drugs, and using most commercially available vaginal lubricants should be discouraged as these might reduce fertility 1.

From the FDA Drug Label

Clomiphene citrate is indicated for the treatment of ovulatory dysfunction in women desiring pregnancy. Properly timed coitus in relationship to ovulation is important A basal body temperature graph or other appropriate tests may help the patient and her physician determine if ovulation occurred. Once ovulation has been established, each course of clomiphene citrate should be started on or about the 5th day of the cycle. Ovulation most often occurs from 5 to 10 days after a course of clomiphene citrate Coitus should be timed to coincide with the expected time of ovulation.

To get pregnant fast, properly timed coitus in relationship to ovulation is important.

• The patient should have adequate levels of endogenous estrogen.
• Impediments to achieving pregnancy must be excluded or adequately treated before beginning clomiphene citrate therapy.
• Coitus should be timed to coincide with the expected time of ovulation, which most often occurs from 5 to 10 days after a course of clomiphene citrate.
• A basal body temperature graph or other appropriate tests may help the patient and her physician determine if ovulation occurred.
• The patient should be evaluated carefully to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between each treatment cycle 2 2.

From the Research

Methods to Get Pregnant Fast

To increase the chances of getting pregnant, several methods can be employed, including:

• Ovulation induction using clomiphene citrate or gonadotropins 3, 4, 5
• Intrauterine insemination (IUI) combined with clomiphene citrate stimulation 4
• Minimal stimulation using gonadotropin combined with clomiphene citrate or letrozole for IUI cycles 6
• Using metformin in combination with clomiphene citrate for ovulation induction in women with polycystic ovary syndrome (PCOS) 7

Ovulation Induction

Ovulation induction can be achieved using:

• Clomiphene citrate, which can be used to treat anovulation due to hypothalamus or pituitary gland dysfunction 3
• Gonadotropins, such as follicle-stimulating hormone (FSH), which can be used as a second-line treatment for ovulation induction in women with PCOS who do not ovulate or conceive on clomiphene citrate or letrozole 5
• Human menopausal gonadotropin (HMG) or highly purified FSH (HP-FSH), which can be used in combination with clomiphene citrate or letrozole for IUI cycles 6

Intrauterine Insemination (IUI)

IUI can be used in combination with ovulation induction to increase the chances of getting pregnant:

• Clomiphene citrate stimulation can be used in combination with IUI to improve fecundity in patients with infertility of unknown origin 4
• Minimal stimulation using gonadotropin combined with clomiphene citrate or letrozole can be used for IUI cycles to reduce the risk of ovarian hyperstimulation syndrome (OHSS) and multiple pregnancies 6

Polycystic Ovary Syndrome (PCOS)

In women with PCOS, the following methods can be used to increase the chances of getting pregnant:

• Clomiphene citrate should be the first-line treatment for ovulation induction in anovulatory patients with PCOS 7
• Metformin can be used in combination with clomiphene citrate for ovulation induction in women with PCOS 7
• Gonadotropins, such as FSH, can be used as a second-line treatment for ovulation induction in women with PCOS who do not ovulate or conceive on clomiphene citrate or letrozole 5