What is the appropriate course of care for a patient presenting with abdominal pain?

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Last updated: April 28, 2025View editorial policy

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Differential Diagnosis for Abdominal Pain

The following differential diagnosis is organized into categories to help guide the thought process for a patient presenting with abdominal pain.

  • Single Most Likely Diagnosis
    • Acute Appendicitis: This is a common cause of abdominal pain, especially in younger patients, and is often characterized by pain that initially presents in the periumbilical region and then localizes to the right lower quadrant.
  • Other Likely Diagnoses
    • Gastroenteritis: Inflammation of the stomach and intestines, usually due to infection, which can cause abdominal pain, diarrhea, and vomiting.
    • Urinary Tract Infection (UTI): Can cause abdominal pain, especially in the lower abdomen, along with symptoms like dysuria and frequent urination.
    • Diverticulitis: Inflammation of the diverticula in the digestive tract, which can cause abdominal pain, usually in the lower left abdomen.
    • Cholecystitis: Inflammation of the gallbladder, often due to gallstones, which can cause right upper quadrant abdominal pain.
  • Do Not Miss Diagnoses
    • Ectopic Pregnancy: A pregnancy that develops outside the uterus, which can cause abdominal pain and vaginal bleeding. Missing this diagnosis can be life-threatening.
    • Ruptured Aortic Aneurysm: A serious condition where the aorta ruptures, causing severe abdominal pain and potentially leading to rapid death if not treated immediately.
    • Intestinal Obstruction: A blockage that prevents normal flow of the products of digestion, which can cause severe abdominal pain, vomiting, and constipation.
    • Pancreatitis: Inflammation of the pancreas, which can cause severe abdominal pain, nausea, and vomiting.
  • Rare Diagnoses
    • Porphyria: A group of disorders that can cause abdominal pain, among other symptoms, due to a buildup of natural chemicals that produce porphyrin in the body.
    • Henoch-Schönlein Purpura (HSP): A form of vasculitis that affects blood vessels and can cause abdominal pain, along with a characteristic rash.
    • Abdominal Migraine: A condition that causes recurrent episodes of severe abdominal pain, often accompanied by other migraine symptoms like headache and nausea.

Each of these diagnoses has a unique set of symptoms and risk factors, and a thorough medical history, physical examination, and diagnostic tests are necessary to determine the underlying cause of abdominal pain in a patient.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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