From the Research
I strongly advise against concurrent use of Adderall and Dexedrine due to the significantly increased risk of serious side effects, including cardiovascular problems, severe anxiety, psychosis, and potential overdose, as supported by the most recent study 1.
Introduction to the Risks
Both medications contain amphetamines, and using them together essentially doubles your stimulant exposure. The potential for adverse effects is a major concern, and the benefits of combining these medications do not outweigh the risks.
Understanding the Medications
- Adderall contains mixed amphetamine salts.
- Dexedrine contains dextroamphetamine.
Evidence-Based Recommendation
The most recent and highest quality study 1 emphasizes the importance of careful consideration when prescribing stimulants, highlighting the need for alternative formulations like the dextroamphetamine transdermal system for patients who have difficulty with oral medications. However, this does not support the concurrent use of Adderall and Dexedrine.
Key Points to Consider
- Safety and Efficacy: The safety and efficacy of stimulants are well-documented, but the risks associated with combining them are not thoroughly studied and are considered dangerous.
- Alternative Approaches: If a patient feels their current medication is not effective, consulting with a healthcare provider about adjusting the current medication or switching to an alternative is the recommended approach.
- Legal and Health Consequences: Self-adjusting stimulant medications or combining prescribed stimulants can lead to serious health consequences, including potential addiction, and legal issues since these are controlled substances.
Conclusion Based on Evidence
Given the potential for serious adverse effects and the lack of evidence supporting the safety of concurrent use, the recommendation is to avoid combining Adderall and Dexedrine. Instead, patients should work closely with their healthcare providers to find the most appropriate and safe treatment plan for their condition, as suggested by the study 1.