What is the recommended oral polio vaccine (OPV) schedule, dosage, and contraindications for administering a live‑attenuated weakened poliovirus?

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Last updated: March 8, 2026View editorial policy

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Give the live‑attenuated oral polio vaccine (OPV) as the oral medication for a weakened polio virus. Use the standard pediatric schedule: administer 0.5 mL of the trivalent OPV (containing the three Sabin strains) orally at ages 2 months, 4 months, and a third dose between 6 and 12 months. Provide a booster dose of 0.5 mL at 4‑5 years of age (or later if the child is at continued risk). Ensure the child is healthy at the time of vaccination; do not give OPV to infants or children with severe immunodeficiency, known HIV infection with severe immunosuppression, or those who have received immunoglobulin within the previous 3 months. If the child cannot receive OPV because of immunocompromise, pregnancy, or severe allergy to vaccine components, use the inactivated polio vaccine (IPV) given intramuscularly in the same age‑based series (typically 4 doses at 2,4,6–18 months, and a booster at 4‑6 years). Monitor for mild adverse effects such as low‑grade fever or transient gastrointestinal upset; rare vaccine‑associated paralytic poliomyelitis warrants immediate medical evaluation.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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