What are the indications for Norgesic (Orphenadrine, Aspirin, Caffeine)?

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Last updated: February 17, 2025View editorial policy

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From the FDA Drug Label

Orphenadrine citrate is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculo-skeletal conditions. The indications for Norgesic (Orphenadrine, Aspirin, Caffeine) are:

  • Relief of discomfort associated with acute, painful musculo-skeletal conditions 1

From the Research

Indications for Norgesic (Orphenadrine, Aspirin, Caffeine)

  • Norgesic is indicated for the treatment of pain due to tension of the cervical and upper thoracic musculature, as well as myalgia nuchae 2
  • The combination of orphenadrine and paracetamol in Norgesic has been shown to be effective in relieving pain and improving symptoms in patients with myalgia 2, 3
  • Caffeine, a component of Norgesic, has been found to have an analgesic adjuvant effect when added to common analgesics such as paracetamol, ibuprofen, and aspirin, enhancing their pain-relieving efficacy 4, 5
  • Norgesic may be used to treat acute postoperative pain, as well as other types of pain, although its efficacy in these conditions may vary 6

Specific Conditions

  • Myalgia nuchae: Norgesic has been shown to be effective in relieving pain and improving symptoms in patients with myalgia nuchae 2
  • Postoperative pain: Norgesic may be used to treat acute postoperative pain, although its efficacy in this condition may vary 6
  • Tension headaches: The combination of orphenadrine and paracetamol in Norgesic may be effective in relieving tension headaches, although further studies are needed to confirm this 3

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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