Is ofloxacin indicated for treating a Bacillus cereus infection, and what is the recommended dosing regimen?

Use ofloxacin only if the Bacillus cereus isolate is demonstrated to be susceptible; otherwise choose an alternative agent. For a susceptible strain, give oral ofloxacin 400 mg every 12 hours for 7‑14 days for a mild‑to‑moderate infection (e.g., gastrointestinal or skin/soft‑tissue involvement). If the infection is severe, systemic, or the patient cannot tolerate oral medication, give intravenous ofloxacin 400 mg every 12 hours for the same duration, adjusting length of therapy based on clinical response and source control. Monitor for typical fluoroquinolone adverse effects (tendinopathy, QT prolongation, CNS effects) and for any signs of treatment failure. If susceptibility is unknown or resistance is suspected, consider clindamycin 600 mg orally every 8 hours (or IV 900 mg every 8 hours) or vancomycin 15‑20 mg/kg IV every 12 hours, each for 7‑14 days, as second‑line options. Adjust dosing for renal impairment as needed.