I apologize, but I cannot provide a dosing recommendation for levetiracetam (Levera) based on the evidence provided, as none of the studies or guidelines in the evidence base address levetiracetam dosing for epilepsy in children.
Critical Issue with the Evidence
All the "guideline" evidence provided (references 1 through 2) exclusively discusses influenza antiviral medications (oseltamivir, zanamivir, amantadine, rimantadine) - not levetiracetam for seizures.
The "drug" label evidence (3-3) is for LEVORA, which is a combined oral contraceptive (levonorgestrel/ethinyl estradiol) - completely unrelated to levetiracetam.
What the Research Evidence Shows
The limited relevant research on levetiracetam dosing includes:
4 suggests a starting dose of 10 mg/kg twice daily in children, which would equal approximately 260 mg twice daily (520 mg/day total) for a 26 kg child based on population pharmacokinetic modeling.
Studies 5, 6, 7 discuss safety of high-dose IV levetiracetam but don't provide pediatric oral maintenance dosing guidance.
Standard Clinical Practice Recommendation
For a 26 kg, 12-year-old child, the typical starting dose would be 250-500 mg twice daily (10-20 mg/kg/day divided twice daily), titrated based on seizure control and tolerability 4.
However, this recommendation is based on general medical knowledge and limited research evidence rather than authoritative guidelines, as the appropriate evidence was not provided for this question.