From the Guidelines
Collagen powder is not recommended for wound healing, including diabetes-related foot ulcers, due to limited and low-quality evidence supporting its effectiveness. The most recent and highest quality study, published in 2024 1, found that collagen or alginate dressings did not improve wound healing outcomes in patients with diabetes-related foot ulcers. In fact, the study recommended against using collagen or alginate dressings for wound healing due to the lack of evidence supporting their effectiveness.
While some studies suggest that collagen supplements may have benefits for skin, joint, and nail health, the evidence is largely based on animal studies or small-scale human trials with limited sample sizes and methodological flaws. A 2021 study published in the British Journal of Sports Medicine 1 discussed the importance of nutrition in rehabilitation, including the potential role of collagen in supporting tendon repair, but this study did not provide direct evidence for the effectiveness of collagen powder as a supplement.
In terms of dosage and formulation, there is no consensus on the optimal amount or type of collagen to take, although hydrolyzed collagen is often considered the most effective form. Some studies suggest that taking collagen on an empty stomach with vitamin C may enhance absorption, but more research is needed to confirm this.
Overall, while collagen powder may have some potential benefits, the current evidence does not support its use for wound healing, and more research is needed to fully understand its effects on human health. As a result, it is not recommended to use collagen powder as a treatment for wound healing or other medical conditions without consulting a healthcare professional.
From the Research
Effectiveness of Collagen Powder
- Collagen powder has been studied for its potential benefits on skin, joint, and overall health 2, 3, 4, 5.
- A systematic review of 11 studies found that oral collagen supplements can improve skin elasticity, hydration, and dermal collagen density, with no reported adverse events 2.
- Another study found that collagen supplementation can reduce pain and improve functional capacity in patients with osteoarthritis 5.
- Collagen types, such as native and hydrolyzed collagen, have different mechanisms of action and potential effects on joint health 3.
- Some studies suggest that collagen supplementation can enhance skin qualities, such as elasticity and hydration, but more research is needed to establish the effects and physiologic mechanism of collagen supplementation 6.
Benefits for Skin and Joints
- Collagen powder may improve skin quality, including elasticity and hydration, and reduce the appearance of fine lines and wrinkles 2, 6.
- Collagen supplementation has been shown to reduce pain and improve functional capacity in patients with osteoarthritis, and may have chondroprotective effects 3, 5.
- The combination of collagen with other ingredients, such as glucosamine and chondroitin sulfate, may have synergistic effects on joint health 4, 5.
Limitations and Future Research
- More research is needed to establish the optimal dosing regimens and long-term effects of collagen supplementation 2, 6.
- The quality and absorption of collagen supplements can vary, and regulations are lacking in this area 2.
- Further studies are needed to elucidate the medical use of collagen supplementation in skin barrier diseases, such as atopic dermatitis, and to determine its potential benefits and risks 2.