What are the effects of a Docusate (Colace) overdose?

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From the Research

If you suspect a Colace (docusate sodium) overdose, seek immediate medical attention by calling poison control at 1-800-222-1222 or going to the emergency room. Colace is a stool softener that is generally safe, and serious overdoses are rare. Symptoms of overdose may include increased diarrhea, abdominal cramping, nausea, vomiting, and electrolyte imbalances in severe cases.

Key Considerations

  • Treatment typically involves supportive care, monitoring for dehydration, and replacing lost fluids and electrolytes 1.
  • The standard recommended dose for adults is 50-300 mg daily, divided into one to three doses.
  • For children, dosing varies by age and should be determined by a healthcare provider.
  • Colace works by decreasing surface tension of stool and intestinal fluids, allowing water and fats to penetrate the stool, making it softer and easier to pass.
  • It's essential to store Colace out of reach of children and to always follow prescribed dosing instructions to prevent accidental overdose.

Recent Evidence

A recent study published in 2021 found that docusate is not effective for constipation in older adults, and its use should be reassessed 2.

Electrolyte Imbalances

Electrolyte imbalances can occur in severe cases of Colace overdose, and treatment should focus on correcting these imbalances and providing supportive care 3, 4.

Monitoring and Treatment

Monitoring for dehydration and electrolyte imbalances is crucial in treating Colace overdose, and treatment should be individualized based on the patient's clinical condition and response to therapy 5, 1.

References

Research

Fluid and Electrolyte Imbalances: Interpretation and Assessment.

Journal of infusion nursing : the official publication of the Infusion Nurses Society, 2016

Research

The Role of Docusate for Constipation in Older People.

The Senior care pharmacist, 2021

Research

Diagnosis and management of electrolyte emergencies.

Best practice & research. Clinical endocrinology & metabolism, 2003

Research

Treatment of electrolyte disorders in adult patients in the intensive care unit.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2005

Research

Diagnosis and management of the drug overdose patient.

American journal of therapeutics, 1997

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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