What are the side effects of Januvia (Sitagliptin)?

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Last updated: February 17, 2025 • View editorial policy

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From the Guidelines

Januvia (Sitagliptin) is associated with several side effects, including pancreatitis, which has been reported but causality has not been established, and postmarketing and bullous pemphigoid, for which discontinuation is recommended if suspected 1.

Common Side Effects

  • Pancreatitis: discontinue if suspected
  • Postmarketing and bullous pemphigoid: discontinue if suspected

Important Considerations

  • Dose adjustment is required based on kidney function for sitagliptin 1.
  • The medication has a neutral effect on major adverse cardiovascular events (MACE), heart failure (HF), and chronic kidney disease (CKD) 1.
  • It is essential to monitor patients for potential side effects and adjust treatment accordingly, particularly in those with pre-existing kidney impairment or at risk for pancreatitis 1.

From the Research

Side Effects of Januvia (Sitagliptin)

There are no research papers provided to assist in answering this question about the side effects of Januvia (Sitagliptin) as the studies mentioned are related to:

  • Serotonin and Norepinephrine Reuptake Inhibitors 2
  • Anti-seizure drugs for epilepsy 3, 4, 5
  • General side effects and challenges associated with anti-epilepsy medication 6

These studies do not provide information about Januvia (Sitagliptin), which is used to treat type 2 diabetes. Some common points from the provided studies include:

  • Side effects of various medications, such as nausea, dizziness, fatigue, and somnolence 2, 3, 6
  • Importance of considering drug-drug interactions and individual patient characteristics when prescribing medications 2, 5
  • Need for careful monitoring and dose adjustments to minimize adverse effects 5

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

2
Research

Serotonin and Norepinephrine Reuptake Inhibitors.

Handbook of experimental pharmacology, 2019

4
Research

Pregabalin add-on for drug-resistant focal epilepsy.

The Cochrane database of systematic reviews, 2022

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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