From the Research
Mood changes from Lupron (leuprolide acetate) typically begin within the first few weeks of treatment, often starting as early as 1-2 weeks after the first injection. These mood-related side effects can include depression, anxiety, emotional lability, irritability, and in some cases, more severe psychiatric symptoms. The onset timing varies between individuals, with some patients experiencing changes within days while others may not notice effects until several weeks into treatment. Lupron works by suppressing sex hormones (estrogen or testosterone), and this hormonal disruption is what leads to mood alterations. The severity and specific mood symptoms depend on factors like dosage (typically 3.75-7.5 mg monthly for women or 7.5-22.5 mg for men), individual sensitivity, treatment duration, and whether supplemental hormone therapy is used. Patients should monitor their mood closely during the first month of treatment and report any concerning changes to their healthcare provider immediately, as dosage adjustments or supportive medications may help manage these side effects. Some studies have investigated the effects of various medications on mood and anxiety disorders, such as the use of lithium and quetiapine for treatment-resistant depression 1, and the efficacy of first-line drugs for the acute treatment of generalized anxiety disorder in adults 2. However, these studies do not provide direct evidence on the time to onset of Lupron mood side effects. Therefore, the recommendation is based on the general understanding of Lupron's mechanism of action and its effects on mood. It is essential to note that the provided evidence does not directly address the question, but the recommendation is made based on the most recent and highest quality study available, which is not directly related to the question but provides some insight into mood and anxiety disorders 1. In clinical practice, it is crucial to prioritize the patient's morbidity, mortality, and quality of life when managing Lupron treatment and potential mood side effects. Key factors to consider include:
- Monitoring mood changes closely during the first month of treatment
- Reporting concerning changes to the healthcare provider immediately
- Considering dosage adjustments or supportive medications to manage side effects
- Individual sensitivity and treatment duration as factors influencing mood symptoms.