What are the effects of dermal exposure to acetone?

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Last updated: April 28, 2025View editorial policy

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From the Guidelines

If acetone contacts your skin, immediately wash the affected area with soap and water for at least 15 minutes to remove the chemical. Acetone is a solvent that can cause skin dryness, irritation, and redness through defatting of skin tissues, as it selectively removes glycerolipids and sterols from the skin, which are necessary for barrier function 1. For mild exposure with minor irritation, apply a gentle, fragrance-free moisturizer after washing to help restore skin moisture. It is essential to note that the skin barrier function can take up to 5-6 days to completely normalize after acetone exposure 1. If irritation persists or if you experience symptoms like severe redness, pain, blistering, or swelling, seek medical attention promptly. Some key considerations when dealing with acetone skin exposure include:

  • Avoid using other solvents to remove acetone as this can worsen irritation
  • Wear appropriate protective equipment, including chemical-resistant gloves (nitrile or butyl rubber, not latex) and clothing that covers exposed skin, when handling acetone
  • Be aware that acetone rapidly evaporates and can penetrate skin, removing natural oils and causing dryness, which is why prompt washing is essential to minimize absorption and potential irritation 1.

From the Research

Acetone Skin Exposure

  • There is no direct evidence in the provided studies regarding acetone skin exposure.
  • The studies focus on topical antimicrobials for burn wound infections and do not mention acetone skin exposure 2, 3, 4.
  • The studies discuss various topical agents, preparations, and methods for combating burn infections, but do not address the effects of acetone on the skin 2, 3, 4.
  • Therefore, there are no research papers to assist in answering this question about acetone skin exposure.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Topical antimicrobials for burn wound infections.

Recent patents on anti-infective drug discovery, 2010

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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