From the Guidelines
The effects of THC can last anywhere from 2-3 hours when inhaled to 5-8 hours when taken orally, with the potential for prolonged effects due to the accumulation of THC in adipose tissue. The duration of THC effects varies significantly based on several factors, including consumption method, dosage, individual metabolism, and frequency of use 1. Immediate effects like euphoria and altered perception peak within seconds to minutes when inhaled and may take 30 minutes to 2 hours to peak with oral ingestion. For occasional users, THC can be detected in urine for a shorter period, while frequent users may test positive for an extended period since THC is stored in fat cells and released slowly.
Psychological effects generally diminish as blood concentrations decrease, though some cognitive effects may persist for an extended period after heavy use. Regular users may develop tolerance, requiring higher doses for the same effects, while also potentially experiencing longer-lasting impairment due to THC accumulation in the body. Complete elimination of THC metabolites can take weeks depending on usage patterns and individual factors. It is essential to consider these factors when using THC, especially for adults with cancer who may be unfamiliar with its effects and potential interactions with other medications 1.
Key factors to consider include:
- Consumption method: inhaled THC has a faster onset and shorter duration compared to oral ingestion
- Dosage: higher doses can lead to longer-lasting effects and increased risk of side effects
- Individual metabolism: factors such as body weight, age, and liver function can influence the duration of THC effects
- Frequency of use: regular users may develop tolerance and experience longer-lasting impairment due to THC accumulation in the body. It is crucial to start with low doses and gradually increase as needed, while also being aware of the potential risks and interactions associated with THC use, particularly in adults with cancer 1.
From the Research
Effects of THC Use
- The effects of THC use can last for several hours, with the intensity and duration of symptoms proportional to the concentration of THC in the blood 2.
- THC is converted into a carboxylic derivative and partitions into fat, where it can be detected in urine for weeks after use 2.
- The "next day" effects of THC use are still being researched, with some studies finding no significant impairment in cognitive function and safety-sensitive tasks 3.
- However, other studies have reported "next day" effects of THC on cognitive function and safety-sensitive tasks, although these studies were often of lower quality 3.
Duration of THC Effects
- The duration of THC effects can vary depending on the dose and method of consumption 2.
- THC can cause cognitive and psychomotor impairment, but the duration of these effects is not well established 3.
- Some studies have found that THC can impair performance on safety-sensitive tasks for up to 24 hours after use, but these findings are not consistent across all studies 3.
Factors Influencing THC Effects
- The effects of THC can be influenced by individual factors, such as tolerance and sensitivity 2.
- The method of consumption, such as smoking or oral ingestion, can also affect the duration and intensity of THC effects 2.
- The presence of other substances, such as cannabidiol (CBD), can also influence the effects of THC 4.