Which condition is not an indication for plasma exchange: Systemic Lupus Erythematosus (SLE), anti-Glomerular Basement Membrane (anti-GBM) disease, Henoch-Schönlein Purpura (HSP), Pauci-Immune Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis, or Thrombotic Thrombocytopenic Purpura (TTP)?

From the Research

Conditions and Plasma Exchange

The following conditions are indications for plasma exchange:

• Systemic Lupus Erythematosus (SLE)
• anti-Glomerular Basement Membrane (anti-GBM) disease
• Pauci-Immune Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis
• Thrombotic Thrombocytopenic Purpura (TTP) 1 Some studies suggest that plasma exchange may be beneficial in the treatment of Henoch-Schönlein Purpura (HSP) in adults 2, 3.

Henoch-Schönlein Purpura (HSP) and Plasma Exchange

• HSP is an IgA-mediated systemic small-vessel vasculitis with a predilection for the skin, gastrointestinal tract, joints, and kidneys 4.
• The role of corticosteroids in the treatment of HSP is still controversial, but they may be used as a symptom reliever 5.
• Plasma exchange has been shown to be beneficial in some cases of HSP, particularly in adults with severe disease 2, 3.

Indications for Plasma Exchange

Based on the available evidence, the condition that is not consistently indicated for plasma exchange is:

• Henoch-Schönlein Purpura (HSP), although some studies suggest that plasma exchange may be beneficial in certain cases, particularly in adults with severe disease 2, 3.