How do beta blockers (beta-adrenergic blocking agents) cause retroperitoneal fibrosis?

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From the Research

Mechanism of Beta Blockers

  • Beta blockers, also known as beta-adrenergic blocking agents, work by antagonizing the actions of endogenous adrenergic agonists, such as epinephrine and norepinephrine, at beta-adrenergic receptors 1
  • They can be classified into different types, including selective and non-selective beta blockers, with varying pharmacologic properties 1

Relationship between Beta Blockers and Retroperitoneal Fibrosis

  • There is no direct evidence in the provided studies to suggest a relationship between beta blockers and retroperitoneal fibrosis
  • The studies primarily focus on the pharmacologic differences between beta blockers, their effects on lipid levels, and their interactions with other drugs 2, 1, 3, 4, 5

Potential Side Effects of Beta Blockers

  • Beta blockers can cause various side effects, including changes in lipid levels, such as increased triglycerides and decreased HDL cholesterol 2
  • They can also increase the risk of falls in older individuals, particularly with non-selective beta blockers 3
  • Additionally, beta blockers can interact with other drugs and herbs, leading to potential adverse effects 5

References

1
Research

Pharmacologic differences between beta blockers.

American heart journal, 1984

4
Research

The clinical importance of lipid solubility in beta blockers.

Aviation, space, and environmental medicine, 1981

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