From the Research
Interaction between Phenylephrine and SULT1A1 Enzyme
There are no research papers to assist in answering this question, as none of the provided studies mention the interaction between Phenylephrine and the SULT1A1 enzyme.
Available Information on Phenylephrine
- Phenylephrine is a canonical α1-adrenoceptor-selective agonist 1
- It has been observed to have unexpected effects in preclinical and clinical studies, which cannot be easily explained by its actions on α1-adrenoceptors 1
- Phenylephrine can exert transient beta(2)-vasodilator activity when its predominant alpha-constrictor effects are blocked 2
- It is used to manage hypotension, sedation, attention deficit hypersensitivity disorder (ADHD), and nasal decongestion 3
- There is substantial intersubject variability in blood pressure response to infusion of phenylephrine, but this variability is not attributed to polymorphisms in the coding sequence of the human alpha(1B)-adrenergic receptor 4
Key Findings on Phenylephrine
- Phenylephrine releases noradrenaline in a [Ca2+]o-independent manner 1
- The release of noradrenaline evoked by phenylephrine is not affected by prazosin, but is inhibited by nisoxetine 1
- Phenylephrine has been studied as an antihypotensive drug in various clinical settings, including severe aortic stenosis, decompensated tetralogy of Fallot, and hypotension during cesarean delivery 5