What is the cause of left lower quadrant abdominal pain?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Article Review Status
Submitted
Under Review
Approved

Last updated: April 28, 2025 • View editorial policy

Differential Diagnosis for Left Lower Quadrant Abdominal Pain

Single Most Likely Diagnosis

  • Diverticulitis: This is a common cause of left lower quadrant abdominal pain, especially in older adults. The pain is usually constant and accompanied by tenderness, fever, and changes in bowel habits.

Other Likely Diagnoses

  • Constipation: Can cause left lower quadrant pain due to the accumulation of feces in the sigmoid colon.
  • Irritable Bowel Syndrome (IBS): Characterized by recurring abdominal pain, bloating, and changes in bowel movements, which can include left lower quadrant pain.
  • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause chronic inflammation and pain in the left lower quadrant.
  • Ovarian Cysts or Torsion: In females, ovarian cysts or torsion can cause severe left lower quadrant pain, often accompanied by nausea, vomiting, and fever.

Do Not Miss Diagnoses

  • Ectopic Pregnancy: A life-threatening condition that requires immediate attention, presenting with severe abdominal pain, vaginal bleeding, and missed periods.
  • Appendicitis (if appendix is located in the left lower quadrant): Although the appendix is typically located in the right lower quadrant, in some cases it can be found in the left lower quadrant, causing pain and tenderness.
  • Intestinal Obstruction: A blockage in the intestines can cause severe abdominal pain, vomiting, and constipation, requiring prompt medical attention.
  • Infectious Colitis: Infections like Clostridioides difficile (C. diff) or other bacterial causes can lead to severe colitis, presenting with diarrhea, fever, and abdominal pain.

Rare Diagnoses

  • Colonic Cancer: Although less common, cancer in the sigmoid colon can cause left lower quadrant pain, changes in bowel habits, and weight loss.
  • Splenic Infarction or Rupture: The spleen is located in the left upper quadrant but can cause referred pain to the left lower quadrant in cases of infarction or rupture.
  • Ureteral Calculi (Kidney Stones): Stones in the ureter can cause severe pain that radiates from the flank to the groin, potentially involving the left lower quadrant.
  • Lymphoma: Abdominal lymphoma can cause pain, weight loss, and other systemic symptoms, including left lower quadrant pain due to involvement of abdominal lymph nodes.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.