From the Research
A testosterone level less than 3 ng/dL in a 39-year-old female is abnormally low and warrants medical attention, with treatment options including testosterone replacement therapy to restore levels to the normal female range. The most recent and highest quality study on this topic is from 2024 1, which highlights the benefits and risks of testosterone replacement therapy (TRT) in indicated populations. According to this study, TRT has been associated with improved libido, muscle mass, cognition, and quality of life, but also with side effects such as an increased risk of polycythemia, benign prostate hypertrophy (BPH), prostate cancer, gynecomastia, testicular atrophy, and infertility. Some key points to consider in the management of low testosterone in women include:
- The goal of treatment is to restore testosterone levels to the normal female range (typically 15-70 ng/dL) rather than male levels 2.
- Treatment options may include testosterone replacement therapy, typically starting with low doses such as 2-4 mg of testosterone cream daily or 25-50 mg of testosterone pellets implanted every 3-4 months 2.
- Before starting any treatment, a complete evaluation is necessary to determine the cause of low testosterone, which could include pituitary function tests, adrenal function assessment, and comprehensive hormone panels 3.
- Regular monitoring of testosterone levels and symptoms is essential during treatment to adjust dosing appropriately and watch for side effects like acne, hair growth, or voice deepening 4. It is essential to consult with a healthcare provider for a complete evaluation and to discuss the benefits and risks of TRT, as well as to determine the best course of treatment for individual patients 5.