From the FDA Drug Label
2.5 To Discontinue Bupropion Hydrochloride Extended-Release Tablets (XL), Taper the Dose The FDA drug label does not provide specific instructions on how to taper Wellbutrin, it only mentions to taper the dose when discontinuing Bupropion Hydrochloride Extended-Release Tablets (XL) 1.
From the Research
Tapering off Wellbutrin (bupropion) should always be done under medical supervision, with a gradual dose reduction over 2-4 weeks, as recommended by the most recent clinical practice guidelines 2. When considering tapering off Wellbutrin, it's essential to prioritize the patient's individual health factors, including their current dose and duration of treatment.
- A typical tapering schedule may involve decreasing the dose by half for 1-2 weeks, then by another half for another week before stopping completely.
- For example, if a patient is taking 300mg daily, their doctor might recommend decreasing to 150mg daily for 1-2 weeks, then to 100mg for another week before stopping completely.
- The tapering process may be accompanied by withdrawal symptoms such as irritability, anxiety, headaches, or sleep disturbances, which can be managed with close medical supervision 2.
- It's crucial to note that improper discontinuation of Wellbutrin can lead to more severe withdrawal symptoms or a return of the condition being treated, emphasizing the importance of medical supervision throughout the tapering process.
- While there is limited guidance on dose reductions and managing withdrawal symptoms in clinical practice guidelines, the available evidence suggests that a gradual tapering approach is the most effective way to minimize withdrawal symptoms and ensure a safe discontinuation of the medication 2, 3.