From the Guidelines
Vyvanse (lisdexamfetamine) may potentially contribute to aphthous ulcers (canker sores) due to its stimulant effects, including dry mouth and potential for oral trauma. According to the provided evidence, stimulants like lisdexamfetamine can cause decreased appetite, sleep disturbances, increased blood pressure and pulse, and headaches 1. While the evidence does not directly link Vyvanse to aphthous ulcers, it is reasonable to consider that the medication's side effects could contribute to the development of oral ulcers.
Some key points to consider when taking Vyvanse and experiencing aphthous ulcers include:
- Increasing water intake to combat dry mouth, a common side effect of stimulant medications like Vyvanse
- Maintaining thorough oral hygiene to prevent infection and promote healing
- Avoiding spicy or acidic foods that may irritate existing ulcers
- Considering over-the-counter treatments like topical benzocaine or hydrogen peroxide rinses for symptom relief
If aphthous ulcers persist or are severe, it is essential to consult a healthcare provider, who may recommend:
- Adjusting the Vyvanse dosage or schedule to minimize side effects
- Prescribing special mouth rinses to promote healing and prevent infection
- Suggesting alternative medications if the ulcers significantly impact quality of life, as the goal of treatment should always prioritize reducing morbidity, mortality, and improving quality of life 1.
Most aphthous ulcers heal within 1-2 weeks even without treatment, but proper oral care and management of Vyvanse side effects can help prevent recurrence and minimize the impact on daily life.
From the Research
Apthous Ulcers and Vyvanse
- There is no direct evidence in the provided studies that links apthous ulcers to Vyvanse (lisdexamfetamine) 2, 3, 4, 5, 6.
- The studies primarily focus on the pharmacological properties, clinical effects, and safety profiles of lisdexamfetamine in the treatment of attention-deficit/hyperactivity disorder (ADHD) 2, 3, 4, 5, 6.
- Common adverse events associated with lisdexamfetamine include decreased appetite, insomnia, and small mean increases in blood pressure and pulse rate 3, 4, 6.
- However, apthous ulcers are not mentioned as a potential side effect or adverse event in any of the provided studies 2, 3, 4, 5, 6.
Safety Profile of Lisdexamfetamine
- The safety and tolerability profile of lisdexamfetamine is similar to that of other stimulants, with most treatment-emergent adverse events being mild or moderate in severity 6.
- Long-term studies have shown that the most frequently reported adverse events are similar to those reported in short-term trials, with decreased appetite and insomnia being common 6.
- Post-marketing survey data suggest that the rate of non-medical use of lisdexamfetamine is lower than that for short-acting stimulants and lower than or equivalent to long-acting stimulant formulations 6.