Can ascorbic acid (Vitamin C) be administered before or after exosome serum application?

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Last updated: April 29, 2025View editorial policy

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From the Research

Vitamin C can be used either before or after exosome serum, but it's generally recommended to apply vitamin C first in your morning routine. Apply vitamin C to clean, dry skin, wait about 5 minutes for it to absorb, then follow with your exosome serum. If you prefer using vitamin C in the evening, apply it after cleansing and before the exosome serum. The key is to allow each product to fully absorb before applying the next. Vitamin C works well with exosome products as it provides antioxidant protection while exosomes deliver regenerative benefits. However, if your vitamin C product is very acidic or your skin is sensitive, you might want to use vitamin C in the morning and exosome serum in the evening to prevent potential irritation. Always patch test when combining active ingredients and discontinue use if you experience any redness, burning, or irritation. Some key points to consider when using vitamin C with exosome serum include:

  • The stability of vitamin C derivatives, such as magnesium ascorbyl phosphate, which has been shown to be more stable than ascorbyl palmitate 1
  • The antioxidant activity of vitamin C and its derivatives, which can help protect the skin from damage and promote regeneration 2
  • The potential for vitamin C to enhance the penetration of other skincare products, including exosome serum 3
  • The importance of choosing a stable and effective form of vitamin C, such as sodium ascorbyl phosphate, which has been shown to have antimicrobial and anti-inflammatory effects 4 It's also important to note that the most recent study 3 suggests that magnesium ascorbyl phosphate can be an effective and stable form of vitamin C for topical delivery, and can be used in combination with exosome serum for enhanced benefits.

References

Research

In vitro antioxidant activity and in vivo efficacy of topical formulations containing vitamin C and its derivatives studied by non-invasive methods.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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