What cutaneous manifestations are not associated with underlying malignancy among Dermatomyositis, Erythema necrolyticum migrans, Acanthosis nigricans, and Multiple eruptive seborrheic keratoses?

From the Research

Cutaneous Manifestations Not Associated with Underlying Malignancy

• Dermatomyositis: There is no evidence in the provided studies to suggest that dermatomyositis is not associated with underlying malignancy.
• Acanthosis nigricans: There is no evidence in the provided studies to suggest that acanthosis nigricans is not associated with underlying malignancy.
• Multiple eruptive seborrheic keratoses: There is no evidence in the provided studies to suggest that multiple eruptive seborrheic keratoses is not associated with underlying malignancy.
• Erythema necrolyticum migrans (also known as Necrolytic migratory erythema):
  • This condition can be associated with underlying malignancy, specifically glucagonoma, a type of pancreatic neuroendocrine tumor 1, 2, 3, 4.
  • However, it can also occur in the absence of a pancreatic tumor, in which case it is referred to as pseudoglucagonoma syndrome, and may be associated with other conditions such as liver disease, inflammatory bowel disease, pancreatitis, malabsorption disorders, and other malignancies 5.

Conditions Associated with Erythema Necrolyticum Migrans

• Glucagonoma syndrome: characterized by the presence of an alpha-cell secreting tumor of the pancreas, elevated levels of glucagon, and a characteristic rash called necrolytic migratory erythema 1, 2, 3, 4.
• Pseudoglucagonoma syndrome: occurs in the absence of a pancreatic tumor and may be associated with other conditions such as liver disease, inflammatory bowel disease, pancreatitis, malabsorption disorders, and other malignancies 5.