Prescription Directions (Sig) for 100 mg Intramuscular Injection Every Two Weeks
Inject 100 mg (0.5 mL if using 200 mg/mL concentration, or 1 mL if using 100 mg/mL concentration) intramuscularly into the thigh (vastus lateralis) or gluteal muscle every 2 weeks; dispense appropriate syringes and needles for drawing up and administering the medication.
Complete Prescription Sig
"Inject 100 mg (0.5 mL or 1 mL depending on concentration) intramuscularly into the thigh or buttock every 2 weeks. Rotate injection sites with each dose."
Required Supplies to Include on Prescription
Drawing-Up Supplies
- 18-gauge or 20-gauge needles for withdrawing medication from the vial 1, 2
- 3 mL or 5 mL syringes for drawing up the dose 2
Administration Supplies
- 22-gauge, 1.5-inch needles for intramuscular injection into the thigh (vastus lateralis) for self-administration 1, 3
- 22-gauge, 1.5 to 2-inch needles for gluteal injection when administered by another person 1, 3
- Alcohol swabs for skin preparation 4
Injection Site Selection and Technique
Preferred Sites
- Thigh (vastus lateralis muscle) is the preferred site for self-injection 1, 3
- Gluteal muscle may be used when another person administers the injection 1, 3
- Upper arm is not recommended for self-injection due to difficulty maintaining proper 90-degree angle 4
Rotation Protocol
- Inject at least 1 cm (approximately one adult finger width) away from the previous injection site 4
- Rotate in a consistent direction within the same anatomical zone 4
- Divide each injection zone into quadrants or halves and use one quadrant/half per injection cycle 4
- Change zones regularly to prevent lipodystrophy 4
Administration Instructions
Pre-Injection Preparation
- Allow medication to reach room temperature by leaving it out of the refrigerator for 30-60 minutes before injection, as cold medication increases pain and lipodystrophy risk 4
- Inspect the medication to ensure it is not expired or cloudy 4
- Clean the injection site with an alcohol swab and allow it to air dry completely 4
Injection Technique
- Insert the needle at a 90-degree angle to ensure intramuscular (not subcutaneous) delivery 5, 6, 7
- Use a 1.5-inch needle for thigh injections in most adults 5, 6
- Inject slowly and steadily 7, 8
- Do not inject through clothing 4
Common Pitfalls to Avoid
- Do not use the same injection site repeatedly, as this causes lipodystrophy and unpredictable absorption 4
- Do not inject cold medication directly from the refrigerator, as this increases pain and tissue damage 4
- Do not use needles shorter than 1.5 inches for intramuscular injection, as this risks subcutaneous rather than intramuscular delivery 5, 6
- Do not skip alcohol preparation or inject before the alcohol has dried, as this increases infection risk and causes stinging 4
Storage Instructions
- Store unopened vials in the refrigerator at 2-8°C (36-46°F) 4
- Once opened, store at room temperature (15-30°C or 59-86°F) away from direct sunlight until the manufacturer's expiration date, typically 28 days 4
- Use insulated bags or cooler packs when transporting medication in hot or freezing conditions 4
Example Complete Prescription
Medication: Testosterone cypionate 200 mg/mL (or 100 mg/mL)
Sig: Inject 100 mg (0.5 mL of 200 mg/mL solution OR 1 mL of 100 mg/mL solution) intramuscularly into the thigh or buttock every 2 weeks. Rotate injection sites with each dose.
Dispense:
- 1 vial (10 mL) testosterone cypionate 200 mg/mL (or appropriate volume for 100 mg/mL)
- 6 syringes, 3 mL
- 6 needles, 18-gauge, 1.5-inch (for drawing up)
- 6 needles, 22-gauge, 1.5-inch (for injection)
- Alcohol swabs, box of 100