Can you write the prescription directions (sig) for a 100 mg intramuscular injection every two weeks, including the appropriate syringes for drawing up and administering the dose?

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Last updated: March 12, 2026 • View editorial policy

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Prescription Directions (Sig) for 100 mg Intramuscular Injection Every Two Weeks

Inject 100 mg (0.5 mL if using 200 mg/mL concentration, or 1 mL if using 100 mg/mL concentration) intramuscularly into the thigh (vastus lateralis) or gluteal muscle every 2 weeks; dispense appropriate syringes and needles for drawing up and administering the medication.

Complete Prescription Sig

"Inject 100 mg (0.5 mL or 1 mL depending on concentration) intramuscularly into the thigh or buttock every 2 weeks. Rotate injection sites with each dose."

Required Supplies to Include on Prescription

Drawing-Up Supplies

  • 18-gauge or 20-gauge needles for withdrawing medication from the vial 1, 2
  • 3 mL or 5 mL syringes for drawing up the dose 2

Administration Supplies

  • 22-gauge, 1.5-inch needles for intramuscular injection into the thigh (vastus lateralis) for self-administration 1, 3
  • 22-gauge, 1.5 to 2-inch needles for gluteal injection when administered by another person 1, 3
  • Alcohol swabs for skin preparation 4

Injection Site Selection and Technique

Preferred Sites

  • Thigh (vastus lateralis muscle) is the preferred site for self-injection 1, 3
  • Gluteal muscle may be used when another person administers the injection 1, 3
  • Upper arm is not recommended for self-injection due to difficulty maintaining proper 90-degree angle 4

Rotation Protocol

  • Inject at least 1 cm (approximately one adult finger width) away from the previous injection site 4
  • Rotate in a consistent direction within the same anatomical zone 4
  • Divide each injection zone into quadrants or halves and use one quadrant/half per injection cycle 4
  • Change zones regularly to prevent lipodystrophy 4

Administration Instructions

Pre-Injection Preparation

  • Allow medication to reach room temperature by leaving it out of the refrigerator for 30-60 minutes before injection, as cold medication increases pain and lipodystrophy risk 4
  • Inspect the medication to ensure it is not expired or cloudy 4
  • Clean the injection site with an alcohol swab and allow it to air dry completely 4

Injection Technique

  • Insert the needle at a 90-degree angle to ensure intramuscular (not subcutaneous) delivery 5, 6, 7
  • Use a 1.5-inch needle for thigh injections in most adults 5, 6
  • Inject slowly and steadily 7, 8
  • Do not inject through clothing 4

Common Pitfalls to Avoid

  • Do not use the same injection site repeatedly, as this causes lipodystrophy and unpredictable absorption 4
  • Do not inject cold medication directly from the refrigerator, as this increases pain and tissue damage 4
  • Do not use needles shorter than 1.5 inches for intramuscular injection, as this risks subcutaneous rather than intramuscular delivery 5, 6
  • Do not skip alcohol preparation or inject before the alcohol has dried, as this increases infection risk and causes stinging 4

Storage Instructions

  • Store unopened vials in the refrigerator at 2-8°C (36-46°F) 4
  • Once opened, store at room temperature (15-30°C or 59-86°F) away from direct sunlight until the manufacturer's expiration date, typically 28 days 4
  • Use insulated bags or cooler packs when transporting medication in hot or freezing conditions 4

Example Complete Prescription

Medication: Testosterone cypionate 200 mg/mL (or 100 mg/mL)
Sig: Inject 100 mg (0.5 mL of 200 mg/mL solution OR 1 mL of 100 mg/mL solution) intramuscularly into the thigh or buttock every 2 weeks. Rotate injection sites with each dose.
Dispense:

  • 1 vial (10 mL) testosterone cypionate 200 mg/mL (or appropriate volume for 100 mg/mL)
  • 6 syringes, 3 mL
  • 6 needles, 18-gauge, 1.5-inch (for drawing up)
  • 6 needles, 22-gauge, 1.5-inch (for injection)
  • Alcohol swabs, box of 100

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.