What is the differential diagnosis (DDX) and workup for a 2-year-old (yo) patient presenting with a 1-week history of fever and diarrhea?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 29, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for 2-year-old with 1 week of fever and diarrhea

  • Single most likely diagnosis
    • Viral gastroenteritis: This is the most common cause of fever and diarrhea in a 2-year-old, often caused by rotavirus, norovirus, or adenovirus. The symptoms and age of the patient make this diagnosis highly probable.
  • Other Likely diagnoses
    • Bacterial gastroenteritis: Caused by bacteria such as Salmonella, Shigella, or E. coli, this condition can also present with fever and diarrhea. The presence of blood in the stool or a recent history of antibiotic use might increase the likelihood of a bacterial cause.
    • Parasitic gastroenteritis: Giardiasis is a common parasitic infection in children that can cause prolonged diarrhea and fever.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Intussusception: Although more commonly associated with abdominal pain and bloody stools, intussusception can occasionally present with fever and diarrhea. It's a medical emergency requiring prompt intervention.
    • Inflammatory bowel disease (IBD): Conditions like Crohn's disease or ulcerative colitis can present with chronic diarrhea and fever. Early diagnosis is crucial for management.
    • Hemolytic uremic syndrome (HUS): Typically following a bacterial infection like E. coli O157:H7, HUS can lead to severe kidney failure and is a medical emergency.
  • Rare diagnoses
    • Food poisoning: While not rare in the general population, food poisoning is less common in toddlers and might present with similar symptoms.
    • Chronic infections: Such as tuberculosis or HIV, which can cause chronic diarrhea and fever but are less common in this age group without specific risk factors.
    • Immunodeficiency: Conditions that impair the immune system can lead to recurrent or persistent infections, including those causing fever and diarrhea.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.