What are the treatment options for hyperhidrosis (excessive sweating)?

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Last updated: April 29, 2025 • View editorial policy

From the Research

Hyperhidrosis treatment should begin with topical aluminum chloride solution, as it is the initial treatment in most cases of primary focal hyperhidrosis, according to the most recent and highest quality study 1. The treatment of hyperhidrosis involves a step-wise approach, with the goal of reducing sweating and improving quality of life.

  • For axillary hyperhidrosis, botulinum toxin injections are considered a highly effective treatment option, providing 4-6 months of relief 1, 2.
  • For palmar and plantar hyperhidrosis, iontophoresis is an effective treatment option, with sessions needed 2-3 times weekly initially, then maintenance treatments 1, 2.
  • Oral anticholinergics, such as glycopyrrolate, can be used as adjuncts in severe cases of hyperhidrosis, but may cause side effects like dry mouth and blurred vision 3, 1.
  • Lifestyle modifications, such as wearing breathable fabrics, avoiding spicy foods and caffeine, and stress management techniques, can complement these treatments by reducing sweat triggers. The choice of treatment depends on the severity of symptoms, the location of the hyperhidrosis, and the patient's preferences and medical history.
  • For example, topical glycopyrrolate can be used to treat gustatory hyperhidrosis, with excellent results in 77% of patients 4.
  • Additionally, topical therapies, such as aluminum salts, can be effective in treating primary focal axillary hyperhidrosis 5. It is essential to note that the treatment of hyperhidrosis should be individualized, and patients should be closely monitored for response to treatment and potential side effects.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.