From the Research
For cold sore prevention, a daily lysine supplement of 1,000-3,000 mg is typically recommended. You can start with 1,000 mg daily for maintenance and increase to 3,000 mg during outbreaks or when you feel one coming on. It's best to take lysine supplements in divided doses with meals to improve absorption and reduce potential stomach upset. L-lysine works by competing with arginine, an amino acid that herpes simplex virus needs to replicate. By maintaining higher lysine levels in your body, you may inhibit viral replication and reduce outbreak frequency and severity. For optimal results, consider also reducing foods high in arginine (like nuts, chocolate, and seeds) while increasing lysine-rich foods such as dairy products, fish, chicken, and legumes. If you have kidney disease or other health conditions, consult with your healthcare provider before starting lysine supplements, as high doses may not be appropriate for everyone.
Key Considerations
- The most recent and highest quality study on the topic of herpes simplex virus treatment is from 2020 1, which discusses the use of acyclovir and its analogues, but does not provide specific guidance on lysine supplementation.
- Other studies, such as those from 2003 2, 2008 3, and 2004 4, discuss the use of valacyclovir and other antiviral medications for herpes simplex virus treatment, but do not provide information on lysine supplementation.
- The recommended daily lysine supplement dose of 1,000-3,000 mg is based on general guidelines and may need to be adjusted based on individual patient needs and health status.
Important Notes
- Lysine supplementation may not be suitable for everyone, particularly those with kidney disease or other health conditions.
- It is essential to consult with a healthcare provider before starting lysine supplements, especially if you have any underlying health conditions or are taking other medications.
- A balanced diet that includes lysine-rich foods, such as dairy products, fish, chicken, and legumes, may also help support immune function and reduce the frequency and severity of cold sore outbreaks.