What is the recommended dose of Piracetam (Nootropil) for cerebral vascular accident (CVA) infarction?

From the Research

Recommended Dose of Piracetam for CVA Infarction

• The recommended dose of Piracetam (Nootropil) for cerebral vascular accident (CVA) infarction is not explicitly stated in most of the provided studies, but one study 1 mentions that patients received one intravenous bolus injection of 12 g piracetam, followed by 12 g daily for 4 weeks and maintenance treatment for 8 weeks.
• Another study 2 investigated the pharmacokinetics of piracetam in focal cerebral ischemic rats and found that a single oral dose of 200 mg/kg piracetam significantly reduced infarct volume by 35.77% caused by middle cerebral artery occlusion.
• However, there is no direct evidence from the provided studies to support a specific recommended dose of piracetam for CVA infarction in humans, except for the study 1 which used a dose of 12 g daily.

Safety and Efficacy of Piracetam

• The study 1 found that piracetam in high dosage (up to 24 g/day) may be given to patients with acute stroke without significant adverse effects.
• The study 2 found that piracetam exposure in brain and CSF were 2.4- and 3.1-fold higher, respectively, in ischemic stroke compared to control rats, indicating that piracetam may have a beneficial effect on brain penetration in ischemic stroke conditions.

Comparison with Other Studies

• The other studies provided do not directly address the recommended dose of piracetam for CVA infarction, but rather discuss the efficacy of other treatments such as aspirin 3, tirofiban combined with a Solitaire stent 4, and Shuxuening injection 5 for the treatment of cerebral infarction.