From the Guidelines
The recommended dosage of Trulicity (Dulaglutide) for weight loss is 0.75mg or 1.5mg administered via subcutaneous injection once weekly 1.
Key Points
- The dosage is initiated at 0.75mg once weekly, with the option to increase to 1.5mg if additional glycemic control is required or if the patient tolerates the initial dose 1.
- The treatment duration is individualized based on patient response and weight loss goals.
- It's essential to note that while the provided evidence does not explicitly state the use of Dulaglutide for weight loss, other GLP-1 RAs, such as Liraglutide and Semaglutide, have approved indications for weight management, with specific dosages for this purpose 1.
- However, based on the available information, the dosage of 0.75mg or 1.5mg once weekly is the recommended regimen for Dulaglutide, which may be considered for weight loss in certain patients, particularly those with type 2 diabetes or multiple cardiovascular risk factors 1.
From the FDA Drug Label
The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly. After 4 weeks, the dosage may be increased to 1.5 mg once weekly for additional glycemic control. If additional glycemic control is needed, increase the dosage in 1.5 mg increments after at least 4 weeks on the current dosage. The maximum recommended dosage is 4.5 mg injected subcutaneously once weekly.
The dosage of Trulicity (Dulaglutide) for glycemic control is:
- Starting dose: 0.75 mg once weekly
- Maximum dose: 4.5 mg once weekly However, the FDA drug label does not specifically mention the dosage for weight loss. 2 2
From the Research
Dosage of Trulicity (Dulaglutide) for Weight Loss
- The dosage of Trulicity (Dulaglutide) for weight loss is not explicitly stated in the provided studies as the primary indication for Trulicity is the treatment of type 2 diabetes.
- However, the studies suggest that dulaglutide can lead to weight loss in patients with type 2 diabetes, with doses of 0.75 mg and 1.5 mg being used in the trials 3, 4, 5, 6.
- In the SUSTAIN 7 trial, patients receiving dulaglutide 0.75 mg and 1.5 mg experienced mean body weight reductions of 2.3 kg and 3.0 kg, respectively, compared to baseline 3.
- The AWARD-4 study found that patients receiving dulaglutide 1.5 mg had a significantly greater weight loss compared to those receiving insulin glargine, with a mean weight change difference of -3.23 kg 6.
- The studies suggest that the weight loss effect of dulaglutide is dose-dependent, with higher doses leading to greater weight loss 3, 6.
- It is essential to note that the dosage of Trulicity for weight loss may vary depending on individual patient characteristics and should be determined by a healthcare professional 4, 5, 7.