What is the dosage of Trulicity (Dulaglutide) for weight loss?

From the Guidelines

The recommended dosage of Trulicity (Dulaglutide) for weight loss is 0.75mg or 1.5mg administered via subcutaneous injection once weekly 1.

Key Points

• The dosage is initiated at 0.75mg once weekly, with the option to increase to 1.5mg if additional glycemic control is required or if the patient tolerates the initial dose 1.
• The treatment duration is individualized based on patient response and weight loss goals.
• It's essential to note that while the provided evidence does not explicitly state the use of Dulaglutide for weight loss, other GLP-1 RAs, such as Liraglutide and Semaglutide, have approved indications for weight management, with specific dosages for this purpose 1.
• However, based on the available information, the dosage of 0.75mg or 1.5mg once weekly is the recommended regimen for Dulaglutide, which may be considered for weight loss in certain patients, particularly those with type 2 diabetes or multiple cardiovascular risk factors 1.

From the Research

Dosage of Trulicity (Dulaglutide) for Weight Loss

• The dosage of Trulicity (Dulaglutide) for weight loss is not explicitly stated in the provided studies as the primary indication for dulaglutide is the treatment of type 2 diabetes.
• However, studies have shown that dulaglutide can lead to weight loss in patients with type 2 diabetes, with doses of 0.75 mg and 1.5 mg being commonly used 2, 3, 4, 5.
• A phase 2 trial also evaluated the safety and efficacy of higher doses of dulaglutide (3.0 and 4.5 mg) and found that these doses were superior to placebo in reducing HbA1c and body weight, with a safety profile consistent with the established safety profile for dulaglutide 6.
• The following dosages of dulaglutide have been studied:
  • 0.75 mg once weekly 2, 3, 5
  • 1.5 mg once weekly 2, 3, 4, 5, 6
  • 3.0 mg once weekly 6
  • 4.5 mg once weekly 6

Efficacy of Dulaglutide for Weight Loss

• Studies have shown that dulaglutide can lead to significant weight loss in patients with type 2 diabetes, with a mean weight loss of 2.3 kg to 4.6 kg compared to placebo or other treatments 2, 3, 4.
• The weight loss effect of dulaglutide was found to be dose-dependent, with higher doses leading to greater weight loss 6.
• Dulaglutide has also been shown to improve glycemic control and reduce the risk of major adverse cardiovascular events in patients with type 2 diabetes 2, 3, 5.