What is the dosage of Trulicity (Dulaglutide) for weight loss?

From the Guidelines

The recommended dosage of Trulicity (Dulaglutide) for weight loss is 0.75mg or 1.5mg administered via subcutaneous injection once weekly 1.

Key Points

• The dosage is initiated at 0.75mg once weekly, with the option to increase to 1.5mg if additional glycemic control is required or if the patient tolerates the initial dose 1.
• The treatment duration is individualized based on patient response and weight loss goals.
• It's essential to note that while the provided evidence does not explicitly state the use of Dulaglutide for weight loss, other GLP-1 RAs, such as Liraglutide and Semaglutide, have approved indications for weight management, with specific dosages for this purpose 1.
• However, based on the available information, the dosage of 0.75mg or 1.5mg once weekly is the recommended regimen for Dulaglutide, which may be considered for weight loss in certain patients, particularly those with type 2 diabetes or multiple cardiovascular risk factors 1.

From the FDA Drug Label

2 DOSAGE AND ADMINISTRATION

2.1 Adult Dosage The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly. After 4 weeks, the dosage may be increased to 1.5 mg once weekly for additional glycemic control. If additional glycemic control is needed, increase the dosage in 1.5 mg increments after at least 4 weeks on the current dosage. The maximum recommended dosage is 4.5 mg injected subcutaneously once weekly.

The dosage of Trulicity (Dulaglutide) for weight loss is not explicitly stated in the label, but the recommended dosages for glycemic control are:

• Starting dosage: 0.75 mg once weekly
• Maximum dosage: 4.5 mg once weekly However, the label does not provide information on the dosage for weight loss specifically. 2

From the Research

Dosage of Trulicity (Dulaglutide) for Weight Loss

• The dosage of Trulicity (Dulaglutide) for weight loss is not explicitly stated in the provided studies, but the following dosages were used in the trials:
  • 0.75 mg once weekly 3, 4, 5, 6, 7
  • 1.5 mg once weekly 3, 4, 6, 7
• The studies suggest that dulaglutide can lead to weight loss in patients with type 2 diabetes, with greater weight loss observed at higher doses 3, 6
• The weight loss effects of dulaglutide were observed across different patient subgroups, including those with different baseline body mass index (BMI) levels 5, 6

Efficacy of Dulaglutide for Weight Loss

• Dulaglutide 1.5 mg once weekly was associated with greater weight loss compared to dulaglutide 0.75 mg once weekly and insulin glargine 6
• The proportion of patients achieving weight loss of at least 3%, 5%, or 10% was higher with dulaglutide 1.5 mg once weekly compared to insulin glargine 6
• Dulaglutide-treated patients were more likely to achieve an HbA1c level of less than 7% without weight gain or with weight loss of at least 3% compared to those treated with insulin glargine 6

Safety Profile of Dulaglutide

• The safety profile of dulaglutide was consistent with that reported in adults, with gastrointestinal disorders being the most frequently reported adverse event 3, 4
• The incidence of hypoglycemia was higher with concomitant use of sulfonylureas 5