What is the treatment for Erythrasma (a superficial fungal infection)?

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Last updated: April 29, 2025View editorial policy

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From the FDA Drug Label

Erythrasma: In the treatment of infections due to Corynebacterium minutissimum Erythromycin is indicated for the treatment of Erythrasma, which is caused by Corynebacterium minutissimum 1.

  • The drug is effective in treating this infection.
  • Erythromycin can be used to treat Erythrasma.

From the Research

Erythrasma is best treated with topical 2% mupirocin ointment applied twice daily, as it has been shown to lead to the resolution of the infection in a recent case report 2. The treatment of erythrasma, a bacterial infection of the skin caused by Corynebacterium minutissimum, typically involves the use of topical or oral antibiotics.

  • The most recent and highest quality study, a case report from 2020, found that twice daily topical 2% mupirocin ointment therapy led to the resolution of erythrasma 2.
  • Another study from 2017 also found that mupirocin 2% ointment monotherapy was effective in treating erythrasma, with complete resolution of the infection occurring in all nine patients treated 3.
  • Other treatment options, such as erythromycin and clindamycin, have also been shown to be effective in treating erythrasma, but the most recent and highest quality study supports the use of topical 2% mupirocin ointment 4, 5. It is also important to keep the affected areas dry and to wear loose-fitting, breathable clothing to help prevent the recurrence of the infection.
  • Washing with antibacterial soaps containing benzoyl peroxide or chlorhexidine can also help speed recovery 4.
  • Changing socks daily if feet are affected can also help prevent the recurrence of the infection. Overall, the treatment of erythrasma should be tailored to the individual patient and should take into account the severity of the infection and the patient's medical history.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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