From the Research
PT-141 (bremelanotide) can sometimes cause coughing as a side effect, though it's not among the most commonly reported reactions, and if you're experiencing a cough after using PT-141, you should consider temporarily discontinuing use and consulting with your healthcare provider. The cough may be related to an allergic or inflammatory response to the medication. According to the most recent study 1, the safety profile of bremelanotide is mostly mild to moderate, with the most common adverse events being nausea, flushing, and headache. However, coughing is not explicitly mentioned as a common side effect in this study.
Possible Mechanism and Management
The coughing mechanism might be related to PT-141's action on melanocortin receptors, which are present in various tissues including the respiratory tract, as suggested by the study on the neurobiology of bremelanotide 2. Some users find that proper injection technique (ensuring the medication is administered subcutaneously rather than intramuscularly) and staying well-hydrated before and after administration may help reduce side effects.
Recommendations for Use
PT-141 is typically administered via subcutaneous injection at doses of 1.75 mg approximately 45 minutes before sexual activity, and should not be used more than once in 24 hours or more than 8 times per month, as recommended by the study on the safety profile of bremelanotide 1. If the cough persists or is severe, this could indicate a more serious reaction requiring immediate medical attention, especially if accompanied by difficulty breathing, chest tightness, or facial swelling.
Key Considerations
- The most common adverse events associated with bremelanotide are nausea, flushing, and headache, as reported in the study on the safety profile of bremelanotide 1.
- Bremelanotide has been shown to significantly improve sexual desire and related distress in premenopausal women with hypoactive sexual desire disorder, as demonstrated in the studies on the efficacy of bremelanotide 3, 4.
- Proper use and administration of PT-141, as well as monitoring for potential side effects, are crucial for minimizing risks and maximizing benefits.