From the FDA Drug Label
The most common reactions associated with dropout in the ziprasidone-treated patients were akathisia, anxiety, depression, dizziness, dystonia, rash and vomiting The FDA drug label does not answer the question.
From the Research
I strongly advise against discontinuing Geodon (ziprasidone) 20 mg twice daily without consulting the prescribing healthcare provider, even after only 2 weeks of use with negative side effects. While it may be reasonable to stop this medication due to adverse effects, abrupt discontinuation of antipsychotic medications can sometimes lead to withdrawal symptoms or rebound effects, as noted in various studies 1, 2, 3, 4, 5. The prescribing provider should evaluate the specific side effects the patient is experiencing, as some may be temporary and improve with continued use, while others may warrant immediate discontinuation.
Key Considerations
- The provider might suggest a gradual taper, an alternative medication, or other management strategies based on the patient's specific situation and underlying condition being treated.
- Geodon affects neurotransmitters like dopamine and serotonin in the brain, and sudden changes in these systems can sometimes cause problems, as discussed in the context of antipsychotic treatment 4.
- The provider can also help determine if the side effects are truly from the medication or potentially from another cause, considering the complex interplay of factors in psychiatric treatment 5.
Evidence-Based Decision
Given the potential risks associated with discontinuing antipsychotic medications and the importance of managing side effects, consulting with the prescribing healthcare provider is crucial. This approach ensures that any decision regarding the continuation or discontinuation of Geodon is made with a full understanding of the potential consequences and alternative treatment options, aligning with the principles of evidence-based practice 1, 3.