What causes paresthesia (tingling sensation) in the hands?

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Last updated: February 17, 2025View editorial policy

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Differential Diagnosis for Tingling in Hands

  • Single most likely diagnosis
    • Carpal Tunnel Syndrome: This is the most common cause of tingling in the hands, especially in the thumb, index, and middle fingers. It occurs due to compression of the median nerve at the wrist.
  • Other Likely diagnoses
    • Peripheral Neuropathy: This condition can cause tingling in the hands and feet due to damage to the peripheral nerves, often associated with diabetes, vitamin deficiencies, or alcohol abuse.
    • Radiculopathy: Compression or irritation of the nerve roots in the neck (cervical radiculopathy) can cause tingling in the hands, especially if the C6 or C7 roots are affected.
    • Ulnar Nerve Entrapment: Compression of the ulnar nerve at the elbow or wrist can cause tingling in the little and ring fingers.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Multiple Sclerosis: Although less common, multiple sclerosis can cause tingling in the hands due to demyelination of the central nervous system. Early diagnosis and treatment are crucial to prevent long-term disability.
    • Spinal Cord Compression: Compression of the spinal cord in the neck can cause tingling in the hands, as well as weakness, numbness, and loss of bladder and bowel control. Prompt diagnosis and treatment are necessary to prevent permanent damage.
    • Vasculitis: Inflammation of the blood vessels (vasculitis) can cause tingling in the hands due to decreased blood flow to the nerves. If left untreated, vasculitis can lead to serious complications, including organ damage.
  • Rare diagnoses
    • Guillain-Barré Syndrome: A rare autoimmune disorder that can cause tingling in the hands and feet, as well as muscle weakness and paralysis.
    • Sjögren's Syndrome: An autoimmune disorder that can cause tingling in the hands and feet, as well as dry eyes and mouth.
    • Lyme Disease: A bacterial infection that can cause tingling in the hands and feet, as well as other neurological symptoms, if left untreated.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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