For an insect bite, a low to medium potency prescription topical corticosteroid such as triamcinolone acetonide 0.1% cream or hydrocortisone butyrate 0.1% cream is typically most appropriate. Apply a thin layer to the affected area 2-3 times daily for up to 7 days. These medications work by reducing inflammation, itching, and swelling at the bite site by suppressing the immune response. For more severe reactions, a higher potency option like betamethasone dipropionate 0.05% cream might be prescribed. It's important to follow your healthcare provider's specific instructions, as overuse of topical corticosteroids can lead to skin thinning and other side effects. Additionally, keep the bite clean, avoid scratching, and consider taking an oral antihistamine like diphenhydramine (Benadryl) or cetirizine (Zyrtec) to further reduce itching. If you develop signs of infection (increasing redness, warmth, pus, or fever) or severe allergic reaction (difficulty breathing, facial swelling), seek immediate medical attention.
What is the most effective topical corticosteroid (cortisone) for treating an insect bite?
Last updated: April 30, 2025 • View editorial policy
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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.
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