From the Guidelines
Adult Dosage of Tylenol (Acetaminophen)
The recommended adult dosage of Tylenol (Acetaminophen) is 325-1000mg every 4-6 hours as needed, not to exceed 4000mg in 24 hours 1.
- The FDA recommends limiting daily acetaminophen intake to a maximum of 4g to reduce the risk of severe liver injury from acetaminophen overdosing 1.
- However, due to concerns of hepatic toxicity, it is suggested that providers consider limiting chronic administration of acetaminophen to 3g or less per day 1.
- It is essential to adhere to these guidelines to minimize the risk of liver damage and other adverse effects, especially when using combination opioid-acetaminophen products or in patients with liver disease 1.
- A daily dose of 2-3g of acetaminophen is generally recommended, as patients with liver cirrhosis are at risk of metabolic disorder and prolonged half-life of acetaminophen 1.
From the FDA Drug Label
DIRECTIONS For Arthritis Pain Label • do not take more than directed (see overdose warning) adults • take 2 caplets every 8 hours with water For Muscle Ache and Pain label • do not take more than directed (see overdose warning) adults and children 12 years of age and over • take 2 caplets every 8 hours with water The adult dosage of Tylenol (Acetaminophen) is:
- 2 caplets every 8 hours with water
- Do not take more than 6 caplets in 24 hours
- Do not use for more than 10 days unless directed by a doctor 2