What is the cause of a 2-year-old's erythematous (red), sore, and desquamating (peeling) buttocks?

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Last updated: April 30, 2025View editorial policy

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Differential Diagnosis for a 2-year-old with a Red, Sore, and Peeling Bottom

  • Single most likely diagnosis:
    • Diaper rash (contact dermatitis): This is the most common cause of a red, sore bottom in a 2-year-old, often due to prolonged exposure to urine and feces, friction from the diaper, and potential allergic reactions to diaper materials or wipes.
  • Other Likely diagnoses:
    • Candidal diaper rash: A fungal infection that can cause redness, soreness, and peeling, especially in the folds of the skin, often accompanied by a yeast-like odor.
    • Bacterial diaper rash: Bacterial infections can cause similar symptoms, including redness, swelling, and pus-filled pimples, often with a foul odor.
    • Allergic reaction to diaper wipes or creams: Some children may be allergic to certain ingredients in wipes or creams used for diaper care, leading to an allergic contact dermatitis.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.):
    • Child abuse: Although rare, it's crucial to consider the possibility of physical abuse, especially if the rash pattern is unusual or if there are other signs of trauma.
    • Staphylococcal scalded skin syndrome (SSSS): A rare but serious condition caused by staphylococcal toxins that can lead to widespread skin peeling and requires immediate medical attention.
  • Rare diagnoses:
    • Psoriasis: Although rare in infants, psoriasis can cause red, scaly patches on the skin, including the diaper area.
    • Seborrheic dermatitis: A condition that can cause a red, oily, scaly rash, often in the folds of the skin, including the diaper area.
    • Zinc deficiency: A rare condition that can cause skin lesions and diaper rash-like symptoms, often accompanied by other systemic symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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